Abstract
Familial hypercholesterolemia (FH), characterized by elevated plasma low-density lipoprotein-cholesterol (LDL-C) levels and premature coronary artery disease (CAD), remains mostly underdiagnosed and undertreated. We investigated the prevalence of clinical FH among Chinese patients with premature ST-segment-elevation myocardial infarction (STEMI) and one-year follow-up on their lipid management and cardiovascular events. Four hundred and ninety-eight premature STEMI patients (363men) were enrolled. FH patients were identified using the Dutch Lipid Clinic Network Criteria. Lipid management and cardiovascular events in all patients were assessed. Nineteen patients (3.8%) were diagnosed as definite/probable FH, 211 (42.4%) as possible FH and 268 (53.8%) as unlikely FH. All patients were divided into two main groups: unlikely FH (0-2 points) and possible FH (≥3 points). Possible FH patients were younger (50.1 years vs. 53.5 years) with higher NT-proBNP level (3014.15 pg/mL vs. 2326.25 pg/mL), occurrence of multi-vessel CAD (37.4% vs. 18.3%), lower LVEF (47% vs. 49%) and more severe Killip classification (Class 3, 20.0% vs. 9.7%). Follow-up data were available for 203 patients from the possible FH group and 243 patients from the unli...Continue Reading
References
Aug 24, 2004·American Journal of Epidemiology·Melissa A AustinSteve E Humphries
Jan 11, 2007·JAMA : the Journal of the American Medical Association·Kirsten Bibbins-DomingoMary A Whooley
Mar 6, 2007·PharmacoEconomics·Pearl D GumbsOlaf H Klungel
Oct 13, 2009·Atherosclerosis·A H PijlmanF L J Visseren
Feb 20, 2010·PloS One·Roeland HuijgenBarbara A Hutten
May 7, 2011·The American Journal of Cardiology·Avishay ElisEvan A Stein
May 27, 2011·Journal of Clinical Lipidology·Anne C GoldbergUNKNOWN National Lipid Association Expert Panel on Familial Hypercholesterolemia
Oct 25, 2011·Atherosclerosis·Lisan A NeefjesPim J de Feyter
Aug 16, 2012·The Journal of Clinical Endocrinology and Metabolism·Marianne BennBørge G Nordestgaard
Aug 21, 2013·European Heart Journal·Børge G NordestgaardUNKNOWN European Atherosclerosis Society Consensus Panel
Mar 4, 2014·European Heart Journal·Barbara SjoukeG Kees Hovingh
Mar 8, 2014·Atherosclerosis·Shui-ping ZhaoYong Huo
May 8, 2014·International Journal of Cardiology·Zumin ShiGerald F Watts
Dec 3, 2014·American Heart Journal·Joshua W KnowlesMuin J Khoury
May 23, 2015·Atherosclerosis·Guy De BackerUNKNOWN EUROASPIRE Investigators
Jul 5, 2015·European Heart Journal·David NanchenNicolas Rodondi
Sep 10, 2015·Journal of Clinical Lipidology·Jing PangGerald F Watts
Mar 16, 2016·Circulation·Sarah D de FerrantiR Christopher Sheldrick
Apr 12, 2016·Atherosclerosis·Loukianos S RallidisJonh Lekakis
Apr 17, 2016·Journal of Biomedical Science·Raymond HendersonSteven Watterson
Jun 29, 2016·Journal of cardiology·Erisa Kawada-WatanabeNobuhisa Hagiwara
Sep 30, 2016·Journal of Clinical Lipidology·Martin Bødtker MortensenErling Falk
Nov 9, 2016·American Heart Journal·Sofie Aagaard RerupEmil L Fosbøl
Dec 7, 2016·Journal of Clinical Lipidology·Sha LiJian-Jun Li
Citations
Jan 17, 2019·Current Opinion in Lipidology·Brian TomlinsonElaine Chow
May 30, 2020·Circulation·Pengwei HuAntonio J Vallejo-Vaz
Jun 13, 2018·Scientific Reports·Sha LiJian-Jun Li
Apr 1, 2020·Advances in Therapy·Ashraf RedaMiguel Urina-Triana
Aug 9, 2020·Frontiers in Cardiovascular Medicine·Hui-Wei ShiYue-Jin Yang
Sep 15, 2020·Frontiers in Genetics·Thanh-Huong TruongHong-An Le
Jul 22, 2019·Journal of Clinical Lipidology·Michel FarnierMarianne Zeller
Jun 13, 2020·Journal of Clinical Lipidology·Nicolas DanchinUNKNOWN FAST-MI investigators
May 6, 2021·Lipids in Health and Disease·Hermann YaoMarianne Zeller