Familial hypercholesterolemia in Chinese patients with premature ST-segment-elevation myocardial infarction: Prevalence, lipid management and 1-year follow-up

PloS One
Ranshaka AuckleWenliang Che

Abstract

Familial hypercholesterolemia (FH), characterized by elevated plasma low-density lipoprotein-cholesterol (LDL-C) levels and premature coronary artery disease (CAD), remains mostly underdiagnosed and undertreated. We investigated the prevalence of clinical FH among Chinese patients with premature ST-segment-elevation myocardial infarction (STEMI) and one-year follow-up on their lipid management and cardiovascular events. Four hundred and ninety-eight premature STEMI patients (363men) were enrolled. FH patients were identified using the Dutch Lipid Clinic Network Criteria. Lipid management and cardiovascular events in all patients were assessed. Nineteen patients (3.8%) were diagnosed as definite/probable FH, 211 (42.4%) as possible FH and 268 (53.8%) as unlikely FH. All patients were divided into two main groups: unlikely FH (0-2 points) and possible FH (≥3 points). Possible FH patients were younger (50.1 years vs. 53.5 years) with higher NT-proBNP level (3014.15 pg/mL vs. 2326.25 pg/mL), occurrence of multi-vessel CAD (37.4% vs. 18.3%), lower LVEF (47% vs. 49%) and more severe Killip classification (Class 3, 20.0% vs. 9.7%). Follow-up data were available for 203 patients from the possible FH group and 243 patients from the unli...Continue Reading

References

Aug 24, 2004·American Journal of Epidemiology·Melissa A AustinSteve E Humphries
Mar 6, 2007·PharmacoEconomics·Pearl D GumbsOlaf H Klungel
May 27, 2011·Journal of Clinical Lipidology·Anne C GoldbergUNKNOWN National Lipid Association Expert Panel on Familial Hypercholesterolemia
Aug 16, 2012·The Journal of Clinical Endocrinology and Metabolism·Marianne BennBørge G Nordestgaard
Dec 3, 2014·American Heart Journal·Joshua W KnowlesMuin J Khoury
Apr 17, 2016·Journal of Biomedical Science·Raymond HendersonSteven Watterson

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Citations

Jan 17, 2019·Current Opinion in Lipidology·Brian TomlinsonElaine Chow
Jun 13, 2018·Scientific Reports·Sha LiJian-Jun Li

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