Apr 11, 1992

Familial inclusion body myositis: evidence for autosomal dominant inheritance

Neurology
H E NevilleC A Garcia

Abstract

We report a kindred manifesting clinical features and muscle biopsy findings of inclusion body myositis (IBM). In this family, multiple members were affected in two generations with direct male-to-male and female-to-male transmission. This is the first reported instance of autosomal dominant inheritance in IBM, which usually occurs sporadically or, rarely, may be transmitted as an autosomal recessive disorder.

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Mentioned in this Paper

Genetic Conditions, Dominant
Inclusion Body Myositis (Disorder)
Electron Microscopy
Muscle
Biopsy
Cytoplasmic Inclusion (Cell Structure)
Congenital Chromosomal Disease
Cytochemistry
Myositis, Proliferative

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