Familial leukemias

Current Treatment Options in Oncology
Peter H Wiernik

Abstract

Familial leukemia has been described for more than 50 years but only recently have modern genetic techniques allowed for the investigation of the genome. Genome-wide association studies have identified a number of genetic sites that appear to relate to susceptibility to leukemia in certain families and occasionally to susceptibility to a specific leukemia in general. Many questions remain, including susceptibility to what? An oncogenic virus? An environmental chemical? Mutation of another gene induced by a heritable mutation-promoting gene?.Clinically important facts have been learned. Chronic lymphocytic leukemia (CLL) is by far the most common familial leukemia. Patients with CLL have approximately a 10% chance of a first-degree relative developing CLL, and even a greater chance of one developing monoclonal B-cell lymphocytosis which may be an asymptomatic forme fruste of the neoplasm. Furthermore, there may be an increased incidence of breast cancer in familial CLL pedigrees which raises the question of a common etiology for neoplasms in general, or at least a previously unrecognized relationship among them.

References

Jan 8, 1976·The New England Journal of Medicine·M V ViolaS Spiegelman
Jul 1, 1990·American Journal of Hematology·L RatnerM D Lairmore
Apr 1, 1988·American Journal of Hematology·S DenicH Dosik
Jan 1, 1985·Cancer·Y MiyamotoT Koga
Jan 1, 1987·Leukemia Research·C G BegleyI R Mackay
Sep 22, 1984·Lancet·D A Lillicrap, H Sterndale
Nov 15, 1980·International Journal of Cancer. Journal International Du Cancer·W WeberM Jeannet
Sep 1, 1984·Cancer·H R PetersonL T Yam
Dec 1, 1981·Annals of Internal Medicine·M S GreenbergF P Li
May 1, 1994·British Journal of Haematology·T P LoughranB J Poiesz
Jul 1, 1994·American Journal of Hematology·M Pérez-EncinasS Tome
Apr 1, 1993·American Journal of Hematology·M GramatoviciK S Grewal
Jun 25, 1998·Leukemia & Lymphoma·D MakowerP H Wiernik
Nov 21, 1998·Leukemia·M R YuilleD Catovsky
Oct 16, 1999·American Journal of Human Genetics·M Horwitz, P H Wiernik
Dec 3, 1999·British Journal of Haematology·O PritschG Dighiero
Mar 18, 2000·Leukemia & Lymphoma·V PratesJ Milone
May 31, 2001·British Journal of Haematology·P H WiernikK Brown
Jun 1, 2002·Leukemia·R S HoulstonM R Yuille
Oct 16, 2002·Cancer Genetics and Cytogenetics·Henry T LynchWarren G Sanger
Feb 25, 2003·Cytometry. Part B, Clinical Cytometry·Gerald E MartiNeil Caporaso
Jan 13, 2004·Medical Oncology·Mustafa CetinerMahmut Bayik
Aug 4, 2004·Leukemia Research·Kari Hemminki, Bowang Chen
Aug 25, 2004·Hematology/oncology Clinics of North America·Daniel Catovsky
Sep 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Polly R EtkindPeter H Wiernik
Oct 8, 2005·Seminars in Hematology·Radek Skoda, Josef T Prchal

❮ Previous
Next ❯

Citations

Dec 22, 2019·British Journal of Haematology·Sarah CharrotJude Fitzgibbon
May 31, 2021·Bulletin du cancer·Walid Sabri HamadouZohra Soua

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Breast Cancer: Risk Factors

Breast cancer is a multifactorial disease that is influenced by both environmental and genetic factors. Discover the latest research on the environmental and genetic risk factors for breast cancer here.

Related Papers

The New England Journal of Medicine
Christopher S MulliganStephen P Mulligan
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
S L SlagerJames R Cerhan
© 2021 Meta ULC. All rights reserved