Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study.

PloS One
R NoordamLeiden Longevity Study group

Abstract

Reported findings are inconsistent whether hypothalamic-pituitary-adrenal (HPA) signaling becomes hyperactive with increasing age, resulting in increasing levels of cortisol. Our previous research strongly suggests that offspring from long-lived families are biologically younger. In this study we assessed whether these offspring have a lower HPA axis activity, as measured by lower levels of cortisol and higher cortisol feedback sensitivity. Salivary cortisol levels were measured at four time points within the first hour upon awakening and at two time points in the evening in a cohort comprising 149 offspring and 154 partners from the Leiden Longevity Study. A dexamethasone suppression test was performed as a measure of cortisol feedback sensitivity. Age, gender and body mass index, smoking and disease history (type 2 diabetes and hypertension) were considered as possible confounding factors. Salivary cortisol secretion was lower in offspring compared to partners in the morning (Area Under the Curve = 15.6 versus 17.1 nmol/L, respectively; p = 0.048) and in the evening (Area Under the Curve = 3.32 versus 3.82 nmol/L, respectively; p = 0.024). Salivary cortisol levels were not different after dexamethasone (0.5 mg) suppression be...Continue Reading

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Citations

Oct 5, 2012·European Journal of Endocrinology·Filippo CeccatoCarla Scaroni
May 9, 2014·The Proceedings of the Nutrition Society·Rudi G J Westendorp, Frank H Schalkwijk
Oct 11, 2015·Stress : the International Journal on the Biology of Stress·Steffy W M JansenNicole Y L Oei
Feb 26, 2015·Frontiers in Psychology·Joram C L MossinkJos F Brosschot
Jul 25, 2019·Current Medicinal Chemistry·Paola BrivioRaffaella Molteni
Feb 23, 2019·Frontiers in Endocrinology·Andreas YiallourisElizabeth O Johnson

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