Familial Mediterranean Fever developing in a Japanese kidney transplant recipient

CEN Case Reports
Masahiko YazawaYoshihiko Watarai

Abstract

Familial Mediterranean Fever (FMF) is an auto-inflammatory disease characterized by periodic febrile episodes and sterile polyserositis and is extremely rare in Asian populations. Here, we report a case of FMF in a 61-year-old Japanese man who received a kidney transplant 31 years ago but had to re-start hemodialysis. Although kidney function had been stable since his initial transplant, serum creatinine levels had been increasing over the 2 years prior to his presentation at our hospital, and a periodic fever developed at the same time. Uremic symptoms were observed, and hemodialysis was re-started, prompting the patient to choose to undergo a second kidney transplantation. We re-checked his medical history and conducted further physical examinations. Given that the patient had previously undergone an operation for olecranon bursitis in which pericardial effusion had been identified, we considered the possibility of FMF and conducted a genetic test, which identified the E202Q heterozygous mutation in the MEFV gene. The patient was therefore diagnosed with variant FMF. To our knowledge, this is the first report of a Japanese kidney transplant recipient being diagnosed as an FMF variant. We describe the relationship of FMF and k...Continue Reading

References

Oct 23, 1997·Arthritis and Rheumatism·A LivnehM Pras
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Nov 28, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ekrem ErekKamil Serdengeçti
Jun 24, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cüneyt EnsariErgun Ertug
Jun 26, 2007·European Journal of Pediatrics·Lorenzo CalligarisAlessandro Ventura
Sep 16, 2011·Kidney International·Jean-François CambierJohann Morelle
May 9, 2012·Clinical Rheumatology·Emre ErdemTekin Akpolat
Nov 1, 2012·Medicine·Kiyoshi MigitaKazunaga Agematsu
Dec 18, 2013·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Shigeru NakaiYoshiharu Tsubakihara

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