Familial Mediterranean fever is associated with a wide spectrum of inflammatory disorders: results from a large cohort study.

Rheumatology International
Nuh AtasAbdurrahman Tufan

Abstract

Familial Mediterranean fever (FMF) is characterized by recurrent short-lived/self-limiting inflammatory attacks. Besides these, a substantial number of patients with FMF present with a variety of other inflammatory diseases; however, this issue has not been systematically studied previously. Hence, we aimed to investigate the frequency of inflammatory comorbid diseases in a large FMF cohort. All patients were recruited from "FMF in Central Anatolia (FiCA) Cohort", comprising 971 (mean age 35.3 ± 12 years, 61.5% female) adult subjects. All patients fulfilled Tel Hashomer criteria. Demographic data, FMF disease characteristics, MEFV gene mutations, and comorbid inflammatory diseases were meticulously questioned, and laboratory features and genotype data were retrieved from hospital records. There were comorbid inflammatory diseases in 205 (21.1%) patients. The most common inflammatory disease was spondyloarthritis (12.9%). Other remarkable inflammatory disorders were psoriasis, immunoglobulin A vasculitis/Henoch-Schönlein purpura, Behçet's disease and inflammatory bowel diseases. Cryptogenic organizing pneumonia is a newly defined entity in our cohort which is seemed to be associated with FMF (0.3%). Number of patients with persi...Continue Reading

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Citations

Mar 21, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Thibault FraisseStéphanie Ducharme-Bénard
Aug 21, 2020·Modern Rheumatology·Ayşenur Paç KısaarslanRuhan Düşünsel
Dec 10, 2019·Rheumatology International·Hazan KaradenizAbdurrahman Tufan
Sep 14, 2020·Clinical Rheumatology·Nesrin SenMehmet Engin Tezcan
Oct 20, 2020·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Irene Latour-Álvarez, Antonio Torrelo
Jun 17, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Sümeyra Özdemir ÇiçekRuhan Düşünsel

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