Familial mesothelioma in first degree relatives

Diagnostic Cytopathology
Alexandra M KalogerakiMaria N Tzardi

Abstract

Occupational asbestos exposure is believed to be the primary etiologic link to mesothelioma. However, in the evaluation of familial mesothelioma, it is important to consider the possibility of household exposure to asbestos. In this study, we report a family in which the father with prolonged occupational asbestos exposure developed malignant pleural mesothelioma and his daughter 14 years later mesothelioma in situ with focally early invasion. Several reports of familial aggregations of mesothelioma strongly support that genetic factors in collaboration with environmental exposure may contribute etiologically to an as yet unknown fraction of occurrence of this disease.

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Citations

May 30, 2014·Indian Journal of Occupational and Environmental Medicine·Claudio Bianchi, Tommaso Bianchi
Jan 22, 2013·Revue de pneumologie clinique·J DelourmeA Scherpereel

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