Familial nasopharyngeal carcinoma in Hong Kong: epidemiology and implication in screening.

Familial Cancer
Wai Tong NgAnne W M Lee

Abstract

The pathogenetic mechanism of nasopharyngeal carcinoma (NPC) is still unclear. Its familial aggregation, on the other hand, has been well documented by many epidemiological studies. The objective of this study was to evaluate the clinical characteristics of familial NPC in an endemic region. Between March 1994 and November 2005, 1,202 consecutive patients were treated at our institution. Patients were divided into 2 groups according to their family history: group 1 had at least one first-degree relative with NPC at the time of diagnosis, and group 2 did not. There were 125(10.4%) patients in group 1, 66% of them had diseased siblings, 44% had diseased parents and 2% had diseased offspring. The patients in group 1 were on average about 2 years younger than group 2 at diagnosis (47.9 vs. 49.8, P = 0.04). There were also more stage I-II patients in group 1 (38 [corrected] vs. 23%, P < 0.01). Although the 5 year overall survival was also higher with group 1 (79 vs. 69%, P < 0.01), only age, sex, T classification and N classification were found to be significant independent factors but not family history per se (P = 0.10). Similar findings were observed after excluding screen-detected patients from group 1. The high incidence of fam...Continue Reading

References

Aug 3, 1974·Lancet·E H Williams, G de Thé
Jan 1, 1972·Advances in Cancer Research·J H Ho
Jan 1, 1984·Pathology·A FischerE Cooper
Nov 15, 1980·Cancer·B W GajwaniJ A Beg
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Al-SarrafJ F Ensley
Dec 10, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P O ChappuisW D Foulkes
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Nancy LeeKaren K Fu
Nov 27, 2002·Seminars in Cancer Biology·Yi-Xin Zeng, Wei-Hua Jia
Mar 10, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Shu-Hang NgTzu-Chen Yen
May 6, 2004·The Breast Journal·Takayuki KinoshitaSadako Akashi-Tanaka
Oct 30, 2004·International Journal of Cancer. Journal International Du Cancer·Wai-Tong NgAnne W M Lee
Mar 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Anne W M LeeW H Lau
Mar 10, 2005·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Ngai-Tseung CheungJames H B Kong
Jan 18, 2006·Archives of Otolaryngology--head & Neck Surgery·Kwok Seng LohLuke Tan
Oct 13, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ellen T Chang, Hans-Olov Adami

❮ Previous
Next ❯

Citations

Dec 22, 2011·The Pharmacogenomics Journal·M A Lowery, E M O'Reilly
May 4, 2011·Molecular Cancer·Susanna H HutajuluJaap M Middeldorp
Mar 17, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ismail MatalkaFiras Q Alzoubi
Jan 24, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ching-Yin HoPen-Yuan Chu
Jul 12, 2012·Biochemical and Biophysical Research Communications·Enqing ZhuoJian Zhang
Nov 26, 2016·International Journal of Molecular Sciences·Xin WenNa Liu
Jan 31, 2019·International Journal of Cancer. Journal International Du Cancer·Geok Wee TanLu Ping Tan
Nov 20, 2013·The American Journal of Dermatopathology·Stephanie L ClaassenWalter L Rush
Apr 16, 2014·International Forum of Allergy & Rhinology·Alejandro VazquezJean Anderson Eloy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.