Familial occurrence of spontaneous spinal CSF leaks: underlying connective tissue disorder

Headache
Bahram Mokri

Abstract

Two sisters developed spontaneous cerebrospinal fluid (CSF) leaks from meningeal diverticula. Both had recurrences from non diverticular sites. Both patients, a sister, and their mother had joint hypermobility and there was a strong family history of thoracic and abdominal aorta aneurysms. To my knowledge, this is the first report of familial occurrence of CSF leaks. It also points to the role of a pre-existing dural weakness, likely related to a disorder of connective tissue matrix.

References

Mar 13, 2002·Neurology·Bahram MokriDrahomira Sencakova
Apr 6, 2004·Neurologic Clinics·Bahram Mokri
Apr 4, 2006·Neurosurgery·Aaron A Cohen-GadolJohn L D Atkinson

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Citations

Mar 15, 2011·Journal of Neurosurgery·Wouter I Schievink, M Marcel Maya
Dec 25, 2015·AJR. American Journal of Roentgenology·Peter G KranzLinda Gray
Jul 26, 2014·Journal of Neurology·Allen L PimientaEyal Reinstein
Nov 29, 2008·Cephalalgia : an International Journal of Headache·W I Schievink
Nov 29, 2008·Cephalalgia : an International Journal of Headache·B Mokri
Sep 27, 2014·Current Pain and Headache Reports·Wouter I Schievink, Constance R Deline
Feb 20, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery

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