Familial pancreatic cancer in Italy. Risk assessment, screening programs and clinical approach: a position paper from the Italian Registry

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Marco Del ChiaroItalian Registry for Familial Pancreatic Cancer

Abstract

In Italy, pancreatic cancer is the fifth leading cause of tumor related death with about 7000 new cases per year and a mortality rate of 95%. In a recent prospective epidemiological study on the Italian population, a family history was found in about 10% of patients suffering from a ductal adenocarcinoma of the pancreas (PDAC). A position paper from the Italian Registry for Familial Pancreatic Cancer was made to manage these high-risk individuals. Even though in the majority of high-risk individuals a genetic test to identify familial predisposition is not available, a screening protocol seems to be reasonable for subjects who have a >10-fold greater risk for the development of PDAC. However this kind of screening should be included in clinical trials, performed in centers with high expertise in pancreatic disease, using the least aggressive diagnostic modalities.

References

Aug 1, 1985·British Journal of Cancer·H T LynchJ F Lynch
Sep 21, 1994·Journal of the National Cancer Institute·H T LynchP Peltomäki
Sep 1, 1993·Gut·K P NugentR K Phillips
May 1, 1996·The British Journal of Surgery·C SpertiS Pedrazzoli
Mar 19, 1997·Journal of the National Cancer Institute·A B LowenfelsD C Whitcomb
Apr 21, 1998·Pancreas·J AriyamaJ Sai
May 9, 1998·AJR. American Journal of Roentgenology·P LegmannA Bonnin
Apr 3, 1999·International Journal of Cancer. Journal International Du Cancer·M AarnioH J Järvinen
May 11, 1999·The American Journal of Gastroenterology·G TalaminiG Cavallini
Aug 7, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I MulderH B Bueno-de-Mesquita
Apr 19, 2000·Occupational and Environmental Medicine·I A OjajärviC H Wesseling
Jun 29, 2000·The Medical Clinics of North America·B Davis, A M Lowy
Sep 1, 2000·Gastrointestinal Endoscopy·H R MertzS D Leach
Dec 13, 2000·Gastroenterology·F M GiardielloJ A Offerhaus
Mar 29, 2001·Gastrointestinal Endoscopy·D O'TooleP Ruszniewski
Jun 19, 2001·International Journal of Cancer. Journal International Du Cancer·B Geoffroy-PerezN Andrieu
Jun 21, 2001·Journal of the National Cancer Institute·R Z Stolzenberg-SolomonUNKNOWN ATBC Study
Jul 13, 2001·JAMA : the Journal of the American Medical Association·A B LowenfelsE P DiMagno
Jan 31, 2002·Gastrointestinal Endoscopy·Gordon C Hunt, Douglas O Faigel
May 22, 2002·Surgical Oncology·Buckminster Farrow, B Mark Evers
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·S J Rulyak, T A Brentnall
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·P B KekisM W Büchler
Sep 19, 2002·Journal of the National Cancer Institute·Deborah ThompsonUNKNOWN Breast Cancer Linkage Consortium
Sep 26, 2002·Gastrointestinal Endoscopy·Michael B KimmeyTeresa A Brentnall
Sep 28, 2002·Mutation Research·Kristin E AndersonFred F Kadlubar
Dec 7, 2002·European Journal of Gastroenterology & Hepatology·Ina MulderH Bas Bueno-de-Mesquita

❮ Previous
Next ❯

Citations

Nov 9, 2012·Gut·Marcia Irene CantoUNKNOWN International Cancer of Pancreas Screening (CAPS) Consortium
Nov 16, 2011·ISRN Oncology·Rajiv LochanRichard M Charnley
Aug 21, 2013·International Journal of Colorectal Disease·Volker FendrichDetlef K Bartsch
Jun 11, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Elisabetta BuscariniUNKNOWN Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO), Italian Society of Endoscopy (SIED), Italian So
Jan 16, 2016·BMC Gastroenterology·Martina MughettiRaffaele Pezzilli
Jan 17, 2012·Surgical Oncology·George H SakorafasVasileios Smyrniotis
Jan 28, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Giulia LeonardiMarco Del Chiaro
Jul 28, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E MocciA Carrato
Feb 19, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Marco Del ChiaroUNKNOWN European Study Group on Cystic Tumours of the Pancreas
Jul 18, 2014·World Journal of Gastrointestinal Endoscopy·Gabriele LamiAndrea Galli
Jun 6, 2012·Nature Reviews. Gastroenterology & Hepatology·Detlef K BartschPeter Langer
Sep 19, 2014·World Journal of Gastroenterology : WJG·Marco Del ChiaroCaroline Verbeke
Sep 9, 2016·Updates in Surgery·Marco Del ChiaroUrban Arnelo
Jul 25, 2017·Langenbeck's Archives of Surgery·Ajay V MakerUNKNOWN Diabetes Control and Complications Trial (DCCT) Research Group
Mar 29, 2019·Gut and Liver·Hiroyuki MatsubayashiYoshimi Kiyozumi
Mar 2, 2017·World Journal of Gastroenterology : WJG·Hiroyuki MatsubayashiToru Shimosegawa
Jun 9, 2018·United European Gastroenterology Journal·Marianna SignorettiGabriele Capurso
Jan 31, 2021·Journal of Clinical Medicine·Anja WagnerGabriela Möslein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Ataxia telangiectasia

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Related Papers

Gut
Randall E BrandParticipants of the Fourth International Symposium of Inherited Diseases of the Pancreas
Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Rohit R SharmaKevin K Roggin
Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Giulia LeonardiMarco Del Chiaro
Familial Cancer
Harald Rieder, Detlef K Bartsch
© 2021 Meta ULC. All rights reserved