PMID: 9164689May 1, 1997Paper

"Familial Parkinson's disease"--a case-control study of families

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
R J UittiD B Calne

Abstract

Parkinson's disease (PD) patients frequently report a family history of PD and this may provide etiological clues to PD. It has also been suggested that a report of a negative family history is reliable. We studied the prevalence of PD in relatives of PD patients to assess the reliability of family history and to evaluate possible explanations of "familial PD" (fPD). 81 of 650 (12.5%) PD probands (all PD patients seen at clinic in 4 years) reported a positive family history of PD. Each fPD proband was matched with non-familial PD (nfPD) proband by gender and year of birth. Screening and follow-up questionnaires were mailed to relatives to obtain information concerning pedigree and presence of neurodegenerative disease. Available family members (regardless of disease status) were examined. On examination, 8 persons, said to be "normal" by probands, relatives and themselves, had definite or possible PD (5 fPD, 3 nfPD). The prevalence rate of PD among first and second degree living relatives of probands varied significantly between fPD and nfPD groups (6269/100,000 versus 1190/100,000; p < 0.001). The weighted prevalence (taking into account the proportions of fPD and nfPD within the clinic) was 1822/100,000, a value more than 5 t...Continue Reading

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Citations

Jan 7, 1999·Journal of Geriatric Psychiatry and Neurology·H Payami, S Zareparsi
Nov 10, 2010·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jaya SanyalV R Rao
Sep 17, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Alexei KorchounovNikolay N Yakhno
Sep 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Michael Y ShinoLorene M Nelson
Jun 16, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·William C NicholsUNKNOWN Parkinson Study Group
Dec 20, 2007·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Nathan Pankratz, Tatiana Foroud
Dec 18, 1998·American Journal of Medical Genetics·S ZareparsiH Payami
Aug 5, 2004·Annals of Neurology·Mirthe M PonsenHenk W Berendse
May 1, 2020·NPJ Parkinson's Disease·Jenne TranCedric Bardy
Feb 13, 2021·NPJ Parkinson's Disease·Jenne TranCedric Bardy

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