Familial persistent polyclonal B-cell lymphocytosis

Leukemia & Lymphoma
A HimmelmannJ Fehr

Abstract

We report the occurrence of the syndrome of persistent polyclonal B-cell lymphocytosis in a brother and a sister. Both showed the morphological and immunophenotypic features of this rare disorder. In addition both had mild splenomegaly, increase of serum IgM and serological evidence of previous EBV infection. Of interest, two additional brothers had no evidence of PPBL but were indistinguishable in terms of HLA haplotype (HLA-DR7), smoking habits or evidence of EBV infection. These observations provide additional support for a genetic basis of the syndrome but suggest that pathogenic factors other than those known so far may be required for its full expression.

References

Jul 1, 1995·British Journal of Haematology·C LarcherH P Huemer
Oct 1, 1994·British Journal of Haematology·X TroussardG Flandrin
Feb 1, 1997·British Journal of Haematology·R CarrE Matutes

❮ Previous
Next ❯

Citations

Sep 22, 2006·Annals of Hematology·Louis D de HaanJos G J Pouwels
Jun 28, 2005·Leukemia Research·Manfred MittererHartwig P Huemer

❮ Previous
Next ❯

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.