Familial skin cancer syndromes: Increased melanoma risk

Journal of the American Academy of Dermatology
Katherine J RansohoffKavita Y Sarin

Abstract

Phenotypic traits, such as red hair and freckling, increase melanoma risk by 2- to 3-fold. In addition, approximately 10% of melanomas are caused by inherited germline mutations that increase melanoma risk from 4- to >1000-fold. This review highlights the key genes responsible for inherited melanoma, with an emphasis on when a patient should undergo genetic testing. Many genetic syndromes associated with increased melanoma risk are also associated with an increased risk of other cancers. Identification of these high-risk patients is essential for preventive behavior reinforcement, genetic counseling, and ensuring other required cancer screenings.

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Citations

Mar 15, 2016·The Nurse Practitioner·Theresa Canavan, Wendy Cantrell
Nov 23, 2017·American Journal of Clinical Dermatology·Elisa A RozemanChristian U Blank
Mar 12, 2017·Cancer Metastasis Reviews·Sancy A LeachmanPaola Ghiorzo
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Feb 16, 2021·Dermatology : International Journal for Clinical and Investigative Dermatology·Clare A PrimieroAideen M McInerney-Leo

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