PMID: 9654231Jul 8, 1998Paper

Familial sudden cardiac death associated with a terminal QRS abnormality on surface 12-lead electrocardiogram in the index case

Journal of Cardiovascular Electrophysiology
A GargG K Feld

Abstract

A case is presented of an 18-year-old male who had been resuscitated following an episode of sudden death due to ventricular fibrillation. The patient was noted to have an abnormal deflection in the terminal QRS on surface ECG and an abnormal signal-averaged ECG demonstrating a late potential coincident with the terminal QRS abnormality on the ECG. The patient had easily inducible polymorphic ventricular tachycardia during electrophysiologic study, which was suppressed by quinidine but not by procainamide or beta blockers. The surface ECG and signal-averaged ECG also were normalized by quinidine but not by procainamide or beta blockers. The patient had no further arrhythmias on quinidine for 6 years until he inexplicably discontinued his medication and died suddenly shortly thereafter. The present case may represent a unique familial sudden death syndrome or possibly a variant of the sudden death syndrome associated with right bundle branch block and ST elevation in V1 through V3. Currently available data suggest that, in such patients, an implantable cardioverter defibrillator may provide better protection from sudden death than does antiarrhythmic drug therapy.

References

Nov 1, 1989·The American Journal of Cardiology·T J CohenE W Hancock
Apr 1, 1974·The Journal of Pediatrics·J R McRaeR V Canent
Sep 1, 1994·Journal of Molecular and Cellular Cardiology·M H WuH C Lue
May 1, 1995·British Journal of Pharmacology·R B ClarkW R Giles
Feb 1, 1995·Journal of Cardiovascular Pharmacology·B Le GrandG W John
Jan 15, 1996·Circulation·G X Yan, C Antzelevitch
Apr 1, 1996·Journal of the American College of Cardiology·T MiyazakiS Ogawa
Mar 1, 1997·Journal of Cardiovascular Electrophysiology·J Brugada, P Brugada

❮ Previous
Next ❯

Citations

Aug 13, 2011·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Samuel Lévy, Pascal Sbragia
Oct 24, 2001·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·S D Cohle, B A Sampson
May 9, 2008·The New England Journal of Medicine·Hein J Wellens
May 9, 2008·The New England Journal of Medicine·Michel HaïssaguerreJacques Clémenty
Apr 6, 2000·Pacing and Clinical Electrophysiology : PACE·M DaimonS Ozawa
Oct 31, 2009·Cardiovascular Ultrasound·James Ker, Lorraine du Toit
Feb 18, 2014·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Yuka Mizusawa, Connie R Bezzina
Jul 3, 2013·Current Cardiology Reports·Elena DolmatovaSteven A Lubitz
Jan 21, 2014·Journal of Electrocardiology·Piotr Kukla
Dec 29, 2013·Journal of Electrocardiology·Mikiko NakagawaTetsunori Saikawa
Dec 26, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Erol TülümenMartin Borggrefe
Jan 3, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mikiko NakagawaTetsunori Saikawa
Sep 24, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Koichi MizumakiHiroshi Inoue
Sep 15, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Laurent RotenMichel Haïssaguerre
Nov 26, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Yvonne CristoforettiFiorenzo Gaita
Oct 5, 2010·Current Problems in Cardiology·Cara N Pellegrini, Melvin M Scheinman
Mar 9, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hiroshi WatanabeWataru Shimizu
May 27, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Marek Jastrzebski, Piotr Kukla
May 2, 2013·Journal of Cardiovascular Electrophysiology·Jason D Roberts, Michael H Gollob
Mar 11, 2015·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Peter KuklaAndrés Ricardo Pérez-Riera
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Bernard Belhassen
Sep 2, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Tetsuji ShinoharaHironobu Yoshimatsu
Sep 27, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Saagar MahidaMichel Haissaguerre
May 10, 2001·The American Journal of Medicine·G V Naccarelli, C Antzelevitch
Oct 5, 2010·Journal of the American College of Cardiology·Begoña BenitoStanley Nattel
Feb 11, 2014·International Journal of Cardiology·Mikiko NakagawaTetsunori Saikawa
May 18, 2004·Journal of the American College of Cardiology·Jean-Sylvain HermidaAntoine Leenhardt
May 21, 2016·Frontiers in Cardiovascular Medicine·Jean-Baptiste GourraudVincent Probst
Jun 2, 2017·Journal of Cardiovascular Electrophysiology·Andrea MazzantiSilvia G Priori
Aug 9, 2002·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Takanori Ikeda
Mar 7, 2007·Journal of Cardiovascular Electrophysiology·Manlio F MárquezManuel Cárdenas
Aug 18, 2005·Pacing and Clinical Electrophysiology : PACE·Manlio F MárquezManuel Cárdenas
Jun 20, 2015·Journal of Cardiovascular Medicine·Luigi BiascoFiorenzo Gaita
Jun 13, 2020·Journal of Cardiovascular Electrophysiology·Marco Schiavone, Giovanni Battista Forleo
Sep 15, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Shinsuke MiyazakiMichel Haïssaguerre
Apr 16, 2002·The American Journal of Forensic Medicine and Pathology·Stephen D CohleBeatriz Aguilera
Jul 26, 2016·Frontiers in Physiology·Ben N MercerSaagar Mahida

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.