Familial temporal lobe epilepsy with aphasic seizures and linkage to chromosome 10q22-q24

Epilepsia
Eylert BrodtkorbOrtrud K Steinlein

Abstract

To describe the phenotypic expression of a new family with familial lateral temporal lobe epilepsy with aphasic seizures, and to compare the findings with the clinical features of previously reported families linked to chromosome 10q22-q24. Medical records were collected from 12 living affected members. The patients underwent a personal interview and a clinical neurologic examination. Results from interictal scalp EEGs and neuroimaging examinations were obtained. The cardinal ictal symptom was a brief sensory aphasia in eight of the patients. In four, this was accompanied by auditory symptoms, usually in the form of monotonous unformed sounds. Simple partial seizures with psychic or somatosensory seizures also were present. Visual ictal symptoms and complex partial seizures were absent. All patients had generalized tonic-clonic seizures. Magnetic resonance imaging (MRI) or computed tomography (CT) did not reveal morphologic correlates. Improvement with age seemed to occur in many patients. Significant linkage to chromosome 10q22-q24 was established by testing 17 polymorphic microsatellite markers. The epilepsy of this family appears to represent a variety of autosomal dominant lateral temporal lobe epilepsy. Aphasic seizures an...Continue Reading

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Citations

Sep 3, 2002·Annals of Neurology·Wenli GuOrtrud K Steinlein
Jan 18, 2005·Journal of Neurology·E FlexA T Giallonardo
Sep 17, 2009·Histochemistry and Cell Biology·Manuela MalatestaCarlo Nobile
Apr 14, 2005·Neurogenetics·W GuO K Steinlein
May 24, 2012·Current Neurology and Neuroscience Reports·Roberto MichelucciCarlo Nobile
Jun 20, 2008·Journal of Molecular Neuroscience : MN·Patrícia A O RibeiroIscia Lopes-Cendes
Dec 4, 2003·Epilepsy Research·Eylert BrodtkorbOrtrud K Steinlein
Sep 12, 2013·Epilepsy Research·Lyne ChahineMassimo Pandolfo
Mar 25, 2004·Lancet Neurology·Isabelle Gourfinkel-AnEric LeGuern
Apr 22, 2004·Nature Reviews. Neuroscience·Ortrud K Steinlein
Aug 17, 2004·Epilepsy Currents·William H. Theodore
Dec 20, 2005·Epilepsia·Fernando CendesIscia Lopes-Cendes
Dec 20, 2005·Epilepsia·Frederick AndermannEva Andermann
Jun 11, 2005·Epilepsia·Eylert BrodtkorbOrtrud K Steinlein
Oct 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·M C Dalakas
Jan 1, 2011·Epilepsy Research and Treatment·Laura RigonCarlo Nobile
Sep 8, 2012·Epilepsy Research and Treatment·Annick Salzmann, Alain Malafosse
Sep 8, 2012·Epilepsy Research and Treatment·Robert D G Blair
Feb 15, 2016·Epilepsy Research·Domenico ItalianoEdoardo Ferlazzo
Feb 5, 2009·Human Mutation·Carlo NobilePasquale Striano
Apr 22, 2005·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Petra M C CallenbachOebele F Brouwer
Mar 22, 2018·Expert Review of Neurotherapeutics·Rūta Mameniškienė, Peter Wolf
May 31, 2021·Epilepsy & Behavior : E&B·Iris UnterbergerGerhard Bauer

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