Familial thrombophilia and lifetime risk of venous thrombosis

Journal of Thrombosis and Haemostasis : JTH
Carla Y VossenF R Rosendaal

Abstract

We started a large multicenter prospective follow-up study to provide reliable risk estimates of venous thrombosis in families with various thrombophilic defects. This paper describes data collected at study entry on venous events experienced before study inclusion, i.e. the baseline data. All individuals (probands, relatives) registered in nine European thrombosis centers with the factor (F)V Leiden mutation, a deficiency of antithrombin, protein C or protein S, or a combination of these defects, were enrolled between March 1994 and September 1997. As control individuals, partners, friends or acquaintances of the thrombophilic participants were included. Incidence and relative risk of objectively confirmed venous thrombotic events (VTEs) prior to entry were calculated for the relatives with thrombophilia and the controls. Of the 846 relatives with thrombophilia (excluding probands), 139 (16%) had experienced a VTE with an incidence of 4.4 per 1000 person years. Of the controls, 15 of the 1212 (1%) controls had experienced a VTE with an incidence of 0.3 per 1000 person years. The risk of venous thrombosis associated with familial thrombophilia was 15.7 (95% CI 9.2-26.8) and remained similar after adjustment for regional and sex...Continue Reading

References

Aug 1, 1992·Journal of Internal Medicine·M NordströmT Kjellström
Feb 2, 1991·Lancet·F R RosendaalJ P Vandenbroucke
Dec 1, 1984·The Journal of Clinical Investigation·P C CompC T Esmon
Nov 1, 1981·The Journal of Clinical Investigation·J H GriffinC Wideman
Oct 7, 1995·BMJ : British Medical Journal·C F AllaartE Briët
Jul 1, 1996·Annals of Internal Medicine·P PrandoniM H Prins
May 1, 1997·Annals of Internal Medicine·I MartinelliP M Mannucci
Apr 21, 1999·Lancet·F R Rosendaal

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Citations

Jul 5, 2013·Human Reproduction Update·UNKNOWN ESHRE Capri Workshop Group
Aug 5, 2006·Current Opinion in Hematology·Paolo Simioni
Nov 30, 2007·Journal of Thrombosis and Haemostasis : JTH·A E A DahmF R Rosendaal
Aug 1, 2009·Blood·Sandra J HasstedtEdwin G Bovill
Nov 3, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Valeria Bafunno, Maurizio Margaglione
Nov 22, 2005·Medicinski pregled·Dusanka Obradović
Sep 19, 2014·Current Infectious Disease Reports·Emanuele Durante-MangoniDomenico Iossa
Mar 19, 2015·Thrombosis Research·Matteo Nicola Dario Di MinnoFrancesco Dentali
Aug 12, 2009·Clinics in Laboratory Medicine·Bernard Khor, Elizabeth M Van Cott
Dec 1, 2012·Thrombosis and Haemostasis·Matteo Nicola Dario Di MinnoWalter Ageno
Mar 8, 2005·Journal of Thrombosis and Haemostasis : JTH·F A Spencer, R J Goldberg
Jul 28, 2009·Journal of Thrombosis and Haemostasis : JTH·F R Rosendaal, P H Reitsma
Apr 26, 2006·Journal of Thrombosis and Haemostasis : JTH·C Y VossenUNKNOWN EPCOT Study Group
Dec 2, 2011·Journal of Thrombosis and Haemostasis : JTH·I PabingerF R Rosendaal
Nov 26, 2010·American Journal of Hematology·Bernard Khor, Elizabeth M Van Cott
Mar 24, 2010·American Journal of Hematology·Bernard Khor, Elizabeth M Van Cott
Feb 5, 2010·British Journal of Haematology·Trevor BaglinUNKNOWN British Committee for Standards in Haematology
Apr 15, 2008·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Peter Clark
Apr 1, 2006·Critical Reviews in Clinical Laboratory Sciences·Massimo FranchiniGiuseppe Lippi
Apr 4, 2015·Thrombosis Research·Christelle OrlandoKristin Jochmans
Aug 12, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Anne MunckMarie-Francoise Hurtaud
Jun 17, 2016·Thrombosis and Haemostasis·Marta Crous-BouChristopher Kabrhel
Jun 24, 2008·American Journal of Obstetrics and Gynecology·Christina M Scifres, George A Macones
Feb 24, 2001·The American Journal of Gastroenterology·L AmitranoA Balzano
Dec 18, 2009·Expert Review of Cardiovascular Therapy·Pankaj Sharma, Reya Gohil
Mar 27, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Andrew NicolaidesUNKNOWN International Union of Angiology and Union Internationale du Phlebologie
Aug 31, 2004·Journal of Thrombosis and Haemostasis : JTH·V De Stefano
May 26, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·William CohenPierre-Emmanuel Morange
Jun 25, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Carla Y VossenFrits R Rosendaal
Mar 12, 2021·Seminars in Respiratory and Critical Care Medicine·Manila Gaddh, Rachel P Rosovsky
Mar 17, 2021·Thrombosis Research·Natalie SmithMarilyn Manco-Johnson
May 29, 2021·Child Abuse & Neglect·Avrey ThauAlex V Levin
Jun 1, 2007·Medicina clínica·José A Páramo
Oct 19, 2021·PloS One·Maria Teresa PagliariFlora Peyvandi

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