Familial transmission of two independent saccadic abnormalities in schizophrenia

Schizophrenia Research
R G RossR Freedman

Abstract

Difficulties with inhibiting inappropriate responses, i.e. disinhibition, and problems with spatial memory are both presumed to be a part of the phenotypic expression of the genetic risk for schizophrenia. Schizophrenic probands are impaired on saccadic eye movement tasks which require (a) response inhibition to prepotent stimuli and (b) generation of an accurate response to a remembered or calculated spatial location, but it is unknown how these deficits are inherited. Sixteen schizophrenic probands, their 32 parents, and two normal control groups completed a delayed oculomotor response and an antisaccade task. The parents with a positive ancestral family history for chronic psychosis (n = 8) were presumed to be more likely than their family history-negative spouses to be genetic carriers for schizophrenia. Probands and their positive family history parents had more failures of response inhibition than did normal control groups. However, it was the probands and their negative family history spouses who demonstrated impaired accuracy of the remembered- or antisaccades. Disinhibition may be closely tied to a specific genetic risk for schizophrenia. However, a second familial factor related to the maintenance or manipulation of s...Continue Reading

Associated Clinical Trials

References

Jan 1, 1988·Schizophrenia Bulletin·C B PertM A Markwell
Mar 15, 1986·American Journal of Ophthalmology·P A SievingE L Berson
Feb 1, 1980·The Quarterly Journal of Experimental Psychology·M I Posner
May 1, 1995·Psychological Medicine·T J CrawfordL Henderson
Mar 15, 1995·Biological Psychiatry·A B Sereno, P S Holzman
Oct 1, 1994·The Journal of Pediatrics·L J SmithH F Pabst
Jul 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·R G RossA Radant
Feb 15, 1994·American Journal of Medical Genetics·S P MikkiläK O Simola
Apr 1, 1993·The Journal of Nervous and Mental Disease·R Heun, W Maier
Dec 18, 1995·American Journal of Medical Genetics·M WaldoR Freedman
Jul 5, 1996·Schizophrenia Research·J G HarrisR Freedman
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·R FreedmanW Byerley
Dec 9, 1997·Neurobiology of Aging·A OlincyR Freedman

❮ Previous
Next ❯

Citations

Mar 3, 2005·Psychiatry Research·Diane C GoodingChristie W Matts
Sep 18, 2004·Schizophrenia Research·Deborah L LevyNancy R Mendell
Oct 10, 2002·Biological Psychiatry·Patricia T MichieAssen V Jablensky
Jul 8, 1999·Biological Psychiatry·L E AdlerM C Waldo
Apr 20, 2000·European Journal of Pharmacology·S LeonardR Freedman
Feb 6, 2004·Journal of Psychiatric Research·Ulrich EttingerTonmoy Sharma
Jan 11, 2000·Journal of Psychiatric Research·M C Waldo, R Freedman
Jul 17, 2001·Biological Psychology·J E McDowell, B A Clementz
Jul 6, 2001·Schizophrenia Research·S R SponheimM Beiser
Apr 17, 2002·Schizophrenia Research·Josette G HarrisRobert Freedman
Feb 21, 2002·Schizophrenia Research·Kristin S Cadenhead, David L Braff
Feb 21, 2002·Schizophrenia Research·Janusz K Rybakowski, Alina Borkowska
Aug 2, 2003·Schizophrenia Research·Joanna BrownsteinDeborah L Levy
Dec 16, 1998·Schizophrenia Research·S Warren, R G Ross
Oct 24, 2000·Schizophrenia Research·G K ThakerJ Sherr
Sep 22, 2009·Journal of the International Neuropsychological Society : JINS·Georgie PaulikMurray T Maybery
Dec 29, 2000·The Australian and New Zealand Journal of Psychiatry·K H Lee, L M Williams
Dec 29, 2000·The Australian and New Zealand Journal of Psychiatry·P T MichieA Jablensky
Dec 1, 2006·Schizophrenia Bulletin·Bruce I TuretskyNeal R Swerdlow
May 10, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·F X CastellanosD W Hommer
Sep 4, 2014·Experimental Brain Research·Felicity D A Wolohan, Paul C Knox
Jul 28, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Florence ThibautUNKNOWN WFSBP Task Force on Biological Markers
Jul 1, 2008·Journal of Psychiatric Research·Nadine PetrovskyMichael Wagner
Dec 2, 2011·Annals of the New York Academy of Sciences·Victoria C WingTony P George
Feb 13, 2002·Biological Psychiatry·Jennifer E McDowellDavid L Braff
Nov 30, 2005·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Randal G RossAllen Radant
Jun 30, 2006·Psychophysiology·Samuel B Hutton, Ulrich Ettinger
Mar 1, 2013·Early Intervention in Psychiatry·Tonya WhiteCanan Karatekin
Jul 22, 2004·Current Medical Research and Opinion·Nadège RipollMichel Bourin
Feb 13, 2013·The International Journal of Neuropsychopharmacology·Nadine PetrovskyMichael Wagner
May 10, 2017·Journal of Neuropsychology·Ulrich EttingerVeena Kumari
May 17, 2000·American Journal of Medical Genetics·M E Calkins, W G Iacono
May 19, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hideo UeharaYoshihiko Maehara
Jul 16, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·C BoudetS Dollfus
Sep 6, 2002·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Ming T TsuangStephen V Faraone

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.