Familiality of kidney stone disease in Iceland

Scandinavian Journal of Urology and Nephrology
Vidar O EdvardssonKari Stefansson

Abstract

The aetiology of kidney stones is multifactorial, with environmental and genetic factors contributing to the pathogenesis. The aim of this study was to assess the role of genetic factors in kidney stone disease by examining the heritability of the trait in Icelandic patients. Medical records at all major hospitals and imaging centres in Iceland were searched for diagnostic codes indicative of kidney stones, yielding a cohort of 5954 incident patients with kidney stone disease. The list of patients was cross-matched with a genealogy database that covers the entire Icelandic nation. The risk ratio (RR) and kinship coefficient (KC) were calculated to determine the risk of kidney stones in relatives of stone formers and the relatedness among kidney stone patients. The risk of kidney stones among family members of stone formers was significantly higher than in the general population. In 2959 patients with radiopaque stones, the RR ranged from 2.25 (p<0.001) for first degree relatives of probands (such as parents or siblings) to 1.07 (p<0.01) in fifth degree relatives. Moreover, for confirmed recurrent stone formers the RR of kidney stones in parents and offspring was in excess of 10 (p<0.001). The KC analysis shows that Icelandic pa...Continue Reading

References

Nov 1, 1979·Kidney International·C M JohnsonL T Kurland
Oct 15, 1992·The New England Journal of Medicine·F L CoeJ R Asplin
Feb 1, 1982·American Journal of Epidemiology·R A HiattE M Hunkeler
May 1, 1995·Kidney International·M PragaJ L Rodicio
Jan 1, 1995·The American Journal of Medicine·F L LevyC Y Pak
Jul 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·B HessP Jaeger
Oct 23, 1997·Journal of the American Society of Nephrology : JASN·G C CurhanM J Stampfer
Apr 11, 2000·American Journal of Human Genetics·S SigurğardóttirP Donnelly
Dec 15, 2000·The New England Journal of Medicine·S SveinbjörnsdottirK Stefansson
Feb 13, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rainer RufFriedhelm Hildebrandt
Apr 5, 2003·Kidney International·Kiriaki K StamatelouGary C Curhan
Apr 28, 2004·Archives of Internal Medicine·Gary C CurhanMeir J Stampfer
Oct 23, 2004·Nephron. Physiology·Eric N Taylor, Gary C Curhan
May 25, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vidar EdvardssonRunolfur Palsson
Jan 24, 2006·European Heart Journal·David O ArnarKari Stefansson
Jul 1, 2006·Scandinavian Journal of Urology and Nephrology·Olafur S IndridasonRunolfur Palsson
Jul 3, 2007·Nature·Daniel F GudbjartssonKari Stefansson

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Citations

Sep 21, 2012·Kidney International·Vidar O EdvardssonRunolfur Palsson
Mar 23, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Dorothea NitschDavid A Leon
Aug 15, 2015·Nature Communications·Asmundur OddssonKari Stefansson
Mar 8, 2019·PloS One·Thasinas DissayabutraPiyaratana Tosukhowong
Apr 11, 2020·Acta Paediatrica·Per WändellKristina Sundquist
Jul 7, 2010·Scandinavian Journal of Urology and Nephrology·Mehri IgciA Tuncay Demiryurek
Jun 10, 2017·Scientific Reports·Ragnar P KristjanssonKari Stefansson
Dec 14, 2017·BJU International·Kari HemminkiXinjun Li
Dec 7, 2018·Nature Communications·Egil FerkingstadKari Stefansson
Jan 27, 2019·Journal of Nephrology·Agnieszka PozdzikKhashayar Sakhaee
Jul 7, 2010·Scandinavian Journal of Urology and Nephrology·Nasser ShakhssalimMohaddeseh Azadvari
Mar 30, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Thasinas DissayabutraPiyaratana Tosukhowong
May 28, 2021·Urolithiasis·Thanakorn PungsrinontPa-Thai Yenchitsomanus

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