Familiarity and recollection processes in patients with recent-onset schizophrenia and their unaffected parents.

Psychiatry Research
Andrée-Anne LefèbvreMarc-André Roy

Abstract

Episodic memory deficits are present in patients with schizophrenia (SZ) and their unaffected relatives and could be considered as a cognitive indicator of genetic vulnerability to SZ. The present study, involving patients with SZ as well as their parents, used experimental tasks specifically designed to disentangle the contribution of familiarity and recollection processes to episodic memory. The performance of patients with SZ (n=26) and their unaffected parents (n=35) was compared with that of healthy control groups matched on socio-demographic variables (controls of patients, n=26; controls of parents, n=35) on two memory tasks assessing recollection and familiarity. The first task was designed to investigate item recognition and memory for item-spatial context associations whereas the second targeted item-item associations. The results revealed an overall episodic memory deficit in patients with SZ, encompassing both familiarity and recollection, while unaffected parents showed a dysfunction restricted to the recollection process. Our study highlights differences and similarities in the source of the episodic memory deficit found in patients with SZ and their unaffected parents, and it suggests that recollection could act ...Continue Reading

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Citations

Nov 30, 2011·Schizophrenia Bulletin·John D RaglandCameron S Carter
Nov 19, 2015·Cognitive, Affective & Behavioral Neuroscience·Mathilde HornDelphine Pins
May 9, 2012·Psychiatry Research·Helene HakerWulf Rössler
Sep 11, 2020·Journal of Clinical and Experimental Neuropsychology·Priyadarshee AbhishekMohammad Zia Ul Haq Katshu

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