Abstract
Although the etiology of autism remains to be elucidated, genetic elements significantly contribute to this disorder, and genes on the X chromosome are of special interest because there is a 4:1 predominance of male probands in autism. In the current study, we therefore examined, using the robust transmission disequilibrium test (TDT), possible preferential transmission of variants of a functional monoamine oxidase A (MAO A) promoter region polymorphism for linkage to autism. In the 49 families examined (33 families with one proband and 15 families with two affected siblings), we did not find preferential transmission of MAO A from 33 heterozygous mothers to affected child (TDT chi-square = 0.29, NS). Nor was any significant difference in MAO A allele frequency observed between 43 male autism subjects versus a group of 108 non-autism control subjects (chi-square = 1.23, P = 0.27, NS). However, a trend was observed for an association between IQ in the probands and the MAO A genotype that just attained significance (F = 3.5, P = 0.046, N = 28) in the small group of autism subjects recruited from families with two affected siblings.
References
Mar 1, 1990·Journal of the American Academy of Child and Adolescent Psychiatry·J PivenS E Folstein
Oct 1, 1988·Archives of General Psychiatry·S L SmalleyM A Spence
Dec 1, 1993·Perceptual and Motor Skills·D J Raggio, T W Massingale
Jul 3, 1995·American Journal of Medical Genetics·Y YuvalM Pras
Jan 1, 1995·Psychological Medicine·A BaileyM Rutter
Oct 1, 1994·Journal of Autism and Developmental Disorders·C LordA Le Couteur
Jul 1, 1994·Journal of Child Psychology and Psychiatry, and Allied Disciplines·P BoltonM Rutter
Oct 22, 1993·Science·H G BrunnerB A van Oost
Aug 1, 1996·Current Opinion in Pediatrics·E H Cook, B L Leventhal
Nov 3, 1998·Human Genetics·S Z SabolD Hamer
Mar 11, 1999·Human Molecular Genetics·J DeckertK P Lesch
Jun 8, 1999·Psychiatry Research·J SamochowiecT Sander
Sep 3, 1999·Psychological Medicine·E Fombonne
Apr 18, 2000·Human Molecular Genetics·J A LambA P Monaco
Apr 20, 2000·Journal of Abnormal Child Psychology·M Rutter
Jun 24, 2000·Nature·N J Risch
Jun 27, 2000·Journal of Psychiatric Research·E G JönssonG C Sedvall
Jul 25, 2000·Psychiatry Research·S B ManuckM F Muldoon
Aug 16, 2000·Journal of Neural Transmission·L G SchmidtK P Lesch
Sep 20, 2000·Psychiatric Genetics·A F JormS Easteal
Oct 14, 2000·Molecular Psychiatry·S P HamiltonJ A Knowles
May 30, 2001·American Journal of Medical Genetics·N YirmiyaR P Ebstein
Citations
Jun 21, 2008·Journal of Autism and Developmental Disorders·Jasmin RoohiKenneth D Gadow
Jul 23, 2013·Neuropharmacology·Marco BortolatoJean C Shih
Dec 31, 2003·Neurotoxicology·Kevin Chen
Oct 13, 2006·Molecular Psychiatry·C M Freitag
Jul 2, 2005·Neuropsychobiology·Younger W-Y YuTai-Jui Chen
Apr 9, 2005·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Susan L Santangelo, Katherine Tsatsanis
Mar 10, 2015·Journal of Anxiety Disorders·Núria VoltasJosefa Canals
Mar 22, 2014·Neurochemical Research·A KarmakarK Mukhopadhyay
Dec 23, 2008·Neuroscience Research·Hee Jeong YooSoon Ae Kim
Aug 16, 2003·Clinical Genetics·I L CohenJ J A Holden
Mar 26, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lea K DavisThomas H Wassink
Jun 20, 2006·Journal of Evolutionary Biology·C Badcock, B Crespi
May 4, 2011·Autism Research : Official Journal of the International Society for Autism Research·Flora TassoneIrva Hertz-Picciotto
Feb 9, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jennifer H BarnettPeter B Jones
Feb 8, 2005·Medical Hypotheses·Skirmantas Janusonis
Oct 15, 2005·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Quirino Cordeiro, Homero Vallada
May 30, 2015·Neuroscience and Biobehavioral Reviews·Preeti JaiswalUsha Rajamma
Dec 3, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Deepak VermaUsha Rajamma
Aug 2, 2012·The International Journal of Neuropsychopharmacology·Marco BortolatoJean C Shih
Mar 27, 2015·International Journal of Environmental Research and Public Health·Agnieszka SamochowiecAnna Grzywacz
Jun 28, 2016·BMC Genetics·Arijit KarmakarKanchan Mukhopadhyay
Jan 7, 2004·Molecular Psychiatry·J ConroyL Gallagher
Mar 30, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Marshall B JonesPeter Szatmari
Jul 21, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Manali DasKanchan Mukhopadhyay
Jan 25, 2005·Mental Retardation and Developmental Disabilities Research Reviews·Thomas H WassinkPeter Szatmari
Feb 6, 2017·Journal of Neuroscience Research·Feng GuAbha Chauhan