PMID: 11920849Mar 29, 2002Paper

Family-based and population study of a functional promoter-region monoamine oxidase A polymorphism in autism: possible association with IQ

American Journal of Medical Genetics
N YirmiyaR P Ebstein

Abstract

Although the etiology of autism remains to be elucidated, genetic elements significantly contribute to this disorder, and genes on the X chromosome are of special interest because there is a 4:1 predominance of male probands in autism. In the current study, we therefore examined, using the robust transmission disequilibrium test (TDT), possible preferential transmission of variants of a functional monoamine oxidase A (MAO A) promoter region polymorphism for linkage to autism. In the 49 families examined (33 families with one proband and 15 families with two affected siblings), we did not find preferential transmission of MAO A from 33 heterozygous mothers to affected child (TDT chi-square = 0.29, NS). Nor was any significant difference in MAO A allele frequency observed between 43 male autism subjects versus a group of 108 non-autism control subjects (chi-square = 1.23, P = 0.27, NS). However, a trend was observed for an association between IQ in the probands and the MAO A genotype that just attained significance (F = 3.5, P = 0.046, N = 28) in the small group of autism subjects recruited from families with two affected siblings.

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Citations

Jun 21, 2008·Journal of Autism and Developmental Disorders·Jasmin RoohiKenneth D Gadow
Apr 9, 2005·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Susan L Santangelo, Katherine Tsatsanis
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May 4, 2011·Autism Research : Official Journal of the International Society for Autism Research·Flora TassoneIrva Hertz-Picciotto
Feb 9, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jennifer H BarnettPeter B Jones
Feb 8, 2005·Medical Hypotheses·Skirmantas Janusonis
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May 30, 2015·Neuroscience and Biobehavioral Reviews·Preeti JaiswalUsha Rajamma
Dec 3, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Deepak VermaUsha Rajamma
Aug 2, 2012·The International Journal of Neuropsychopharmacology·Marco BortolatoJean C Shih
Mar 27, 2015·International Journal of Environmental Research and Public Health·Agnieszka SamochowiecAnna Grzywacz
Mar 30, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Marshall B JonesPeter Szatmari
Jul 21, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Manali DasKanchan Mukhopadhyay
Jan 25, 2005·Mental Retardation and Developmental Disabilities Research Reviews·Thomas H WassinkPeter Szatmari

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