Family-based association of FKBP5 in bipolar disorder

Molecular Psychiatry
Virginia L WillourJ B Potash

Abstract

The FKBP5 gene product forms part of a complex with the glucocorticoid receptor and can modulate cortisol-binding affinity. Variations in the gene have been associated with increased recurrence of depression and with rapid response to antidepressant treatment. We sought to determine whether common FKBP5 variants confer risk for bipolar disorder. We genotyped seven tag single-nucleotide polymorphisms (SNPs) in FKBP5, plus two SNPs previously associated with illness, in 317 families with 554 bipolar offspring, derived primarily from two studies. Single marker and haplotypic analyses were carried out with FBAT and EATDT employing the standard bipolar phenotype. Association analyses were also conducted using 11 disease-related variables as covariates. Under an additive genetic model, rs4713902 showed significant overtransmission of the major allele (P=0.0001), which was consistent across the two sample sets (P=0.004 and 0.006). rs7757037 showed evidence of association that was strongest under the dominant model (P=0.001). This result was consistent across the two datasets (P=0.017 and 0.019). The dominant model yielded modest evidence for association (P<0.05) for three additional markers. Covariate-based analyses suggested that gen...Continue Reading

References

Jul 1, 1978·Archives of General Psychiatry·J Endicott, R L Spitzer
Jan 1, 1988·Journal of Psychiatric Research·R L Spitzer, J B Williams
Jul 1, 1994·Journal of Psychiatric Research·I HeuserF Holsboer
Nov 14, 1997·The American Journal of Psychiatry·J C Nelson, J M Davis
Mar 24, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S ModellF Holsboer
Feb 18, 1999·The Journal of Clinical Endocrinology and Metabolism·P D ReynoldsJ G Scammell
Mar 20, 1999·Genetic Analysis : Biomolecular Engineering·K J Livak
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·S D Detera-WadleighE S Gershon
Sep 30, 1999·Journal of Psychiatric Research·J K Rybakowski, K Twardowska
May 25, 2002·Science·Stacey B GabrielDavid Altshuler
Feb 15, 2003·American Journal of Human Genetics·Adele A MitchellAravinda Chakravarti
Nov 6, 2003·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Jordan W Smoller, Christine T Finn
Dec 19, 2003·American Journal of Human Genetics·Christopher S CarlsonDeborah A Nickerson
Jun 3, 2004·The British Journal of Psychiatry : the Journal of Mental Science·Stuart WatsonAllan H Young
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Jul 19, 2005·Genome Research·Adam SiepelDavid Haussler
Sep 30, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dirk van WestStephan Claes
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Apr 4, 2006·Biological Psychiatry·Elisabeth F C van RossumFlorian Holsboer
Sep 26, 2006·Journal of Affective Disorders·Ronald C KesslerPaul E Stang
Oct 24, 2006·Psychoneuroendocrinology·Mark A EllenbogenSebastien Adam
Apr 4, 2007·The American Journal of Psychiatry·Zola N ManniePhilip J Cowen
Jun 8, 2007·Nature·UNKNOWN Wellcome Trust Case Control Consortium
Aug 3, 2007·The American Journal of Psychiatry·James B PotashFrancis J McMahon
Jul 26, 2008·Nature Nanotechnology

❮ Previous
Next ❯

Citations

Jan 4, 2012·Archives of General Psychiatry·Laura BevilacquaMary-Anne Enoch
Jan 22, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alec RoyMary-Anne Enoch
Oct 24, 2009·Médecine sciences : M/S·Quentin RainerDenis J David
May 25, 2011·Genes, Brain, and Behavior·Y J Ben-EfraimM Sokolowski
Oct 1, 2012·Acta Neuropsychiatrica·Raúl Ventura-Junca, Luisa M Herrera
May 18, 2013·BMC Medicine·Uzoezi OzomaroCharles B Nemeroff
May 2, 2009·Disease Models & Mechanisms·Oz MalkesmanHusseini K Manji
Feb 25, 2011·PloS One·Sebastian H ScharfMarianne B Müller
Sep 22, 2011·PloS One·John C O'LearyChad A Dickey
Oct 31, 2014·Nature Reviews. Neuroscience·Gustavo Turecki
May 23, 2014·Psychoneuroendocrinology·O LevranM J Kreek
Aug 16, 2013·BMC Psychiatry·Fayaz SeifuddinPeter P Zandi
Apr 21, 2009·FEBS Letters·Anna LaengerTheo Rein
Aug 29, 2013·Alcohol·Jeanette N McClintickHoward J Edenberg
Jan 26, 2016·Biological Psychiatry·Cynthia Shannon WeickertDuncan Sinclair
Oct 28, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shih-Jen TsaiYing-Jay Liou
Aug 31, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Nils Eiel SteenOle A Andreassen
Jul 1, 2009·Pharmacology & Therapeutics·Sonja Horstmann, Elisabeth B Binder
Aug 8, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anthony S ZannasElisabeth B Binder
Oct 2, 2015·Journal of Psychiatric Research·Melissa J GreenUNKNOWN Australian Schizophrenia Research Bank
Jan 31, 2013·Bipolar Disorders·Haiming ChenMelvin G McInnis
May 3, 2012·Journal of Neurochemistry·Natalia M GalignianaMario D Galigniana
Dec 12, 2012·Psychoneuroendocrinology·José M Pérez-OrtizJorge Manzanares
Aug 25, 2015·The Psychiatric Clinics of North America·Lujain Alhajji, Charles B Nemeroff
Jan 1, 2015·Neurobiology of Stress·Johannes M H M ReulAstrid C E Linthorst
Dec 19, 2014·The International Journal of Neuropsychopharmacology·Gabriel Rodrigo FriesMárcia Kauer-Sant'Anna
May 27, 2014·Journal of Affective Disorders·Aleksandra SzczepankiewiczJoanna Twarowska-Hauser
Mar 17, 2010·Journal of Affective Disorders·Catharina LavebrattYvonne Forsell
Jul 28, 2013·Neuroscience and Biobehavioral Reviews·Laura Mandelli, Alessandro Serretti
Jan 17, 2015·Schizophrenia Bulletin·Nikolaos P Daskalakis, Elisabeth B Binder

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