Family-based association studies of CAPON and schizophrenia in the Chinese Han population

Progress in Neuro-psychopharmacology & Biological Psychiatry
C FangY Y Shi

Abstract

Although there is evidence pointing to CAPON as a susceptible gene for schizophrenia, the results of independent association studies have so far been inconsistent. A recent case-control study by Zheng et al. supported CAPON as a susceptible site for the disease in the Chinese Han population. In their study both the single polymorphism (rs348624) and individual haplotypes showed significant association with schizophrenia. Our study further investigates this relationship this time using a family-based association. We selected 5 SNPs including rs348624 and performed a Transmission Disequilibrium Test (TDT) in 319 Chinese Han trios. Our results identified no single marker nor haplotype associated with schizophrenia, which did not suggest that CAPON was a susceptible site in the Chinese Han population, or it appeared unlikely that the CAPON played a major role in the aetiology of schizophrenia. Since there is consistent evidence pointing to 1q21-22 as a positional candidate region for schizophrenia, we suggest that further research should focus on other genes located in this region.

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Citations

Jul 7, 2010·BMC Medical Genetics·Richard DelormeThomas Bourgeron
Jun 1, 2012·Revista colombiana de psiquiatría·Jenny García ValenciaGabriel Bedoya Berrío
Sep 19, 2015·Journal of Affective Disorders·Sern-Yih CheahJoanne Voisey
Jul 7, 2009·Neuroscience Letters·Chen ZhangShunying Yu
Oct 31, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Aihua YuanShunying Yu
Nov 14, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·H WeberA Reif
Oct 23, 2016·Comprehensive Psychiatry·Sern-Yih CheahJoanne Voisey

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