Family-based designs in the age of large-scale gene-association studies

Nature Reviews. Genetics
Nan M Laird, Christoph Lange

Abstract

Both population-based and family-based designs are commonly used in genetic association studies to locate genes that underlie complex diseases. The simplest version of the family-based design--the transmission disequilibrium test--is well known, but the numerous extensions that broaden its scope and power are less widely appreciated. Family-based designs have unique advantages over population-based designs, as they are robust against population admixture and stratification, allow both linkage and association to be tested for and offer a solution to the problem of model building. Furthermore, the fact that family-based designs contain both within- and between-family information has substantial benefits in terms of multiple-hypothesis testing, especially in the context of whole-genome association studies.

References

Jan 1, 1989·Genetic Epidemiology·J Ott
Sep 13, 1996·Science·N Risch, K Merikangas
Aug 1, 1997·American Journal of Human Genetics·E R MartinB S Weir
Apr 16, 1998·American Journal of Human Genetics·R S Spielman, W J Ewens
Aug 27, 1998·American Journal of Human Genetics·J C Whittaker, C M Lewis
Dec 5, 1998·American Journal of Human Genetics·S Horvath, N M Laird
Jan 23, 1999·American Journal of Human Genetics·D W FulkerJ K Hewitt
Mar 26, 1999·American Journal of Human Genetics·C R Weinberg
Jun 12, 1999·American Journal of Human Genetics·C R Weinberg
Jul 27, 1999·American Journal of Human Genetics·J C Whittaker, C M Lewis
Jan 13, 2000·American Journal of Human Genetics·D M Umbach, C R Weinberg
Jan 13, 2000·American Journal of Human Genetics·G R AbecasisW O Cookson
Mar 21, 2000·American Journal of Human Genetics·K L LunettaN M Laird
Mar 31, 2000·American Journal of Human Genetics·A S Whittemore, I P Tu
Oct 31, 2000·Genetic Epidemiology·N M LairdX Xu
Nov 4, 2000·American Journal of Human Genetics·S L LakeN M Laird
Nov 30, 2000·Human Heredity·O MokliatchoukD Rabinowitz
Apr 21, 2001·European Journal of Human Genetics : EJHG·S HorvathN M Laird
Jul 31, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S T Weiss
Jan 15, 2002·Genetic Epidemiology·Mei-Chiung Shih, Alice S Whittemore
May 31, 2002·Behavior Genetics·Ralph McGinnisAriel Darvasi
Aug 16, 2002·American Journal of Human Genetics·Christoph Lange, Nan M Laird
Nov 28, 2002·American Journal of Human Genetics·Christoph LangeNan M Laird
Jan 21, 2003·American Journal of Human Genetics·Clarice R Weinberg
Aug 14, 2003·Genetic Epidemiology·Frank Dudbridge
Sep 23, 2003·American Journal of Human Genetics·Christoph LangeNan M Laird
Dec 19, 2003·American Journal of Human Genetics·Sebastian ZöllnerJonathan K Pritchard
Jan 13, 2004·Statistics in Medicine·Christoph LangeNan M Laird
Jan 24, 2004·American Journal of Human Genetics·Christoph LangeNan M Laird
Mar 31, 2004·Nature Genetics·Matthew L FreedmanDavid Altshuler
Jun 9, 2004·Genetic Epidemiology·Emily O Kistner, Clarice R Weinberg

❮ Previous
Next ❯

Citations

Jul 9, 2008·Archives of General Psychiatry·Peter P ZandiUNKNOWN National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium
Sep 17, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Agostino FricanoLuigi Cattivelli
Apr 27, 2013·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Baohong GuoWilliam D Beavis
Aug 7, 2012·Human Genetics·Stijn Vansteelandt, Christoph Lange
Oct 3, 2008·Neurogenetics·Brit-Maren M SchjeideLars Bertram
Aug 27, 2013·Journal of the Association for Research in Otolaryngology : JARO·E Kaitlynn AllenMichèle M Sale
Nov 2, 2011·Behavior Genetics·Sarah H StephensMarissa A Ehringer
Dec 23, 2008·Molecular Biotechnology·Bing Yu
May 15, 2008·Heredity·S C González-MartínezD B Neale
Feb 28, 2007·Nature Genetics·Matthew B McQueenChristoph Lange
Mar 10, 2010·Nature Reviews. Genetics·Duncan Thomas
Jun 16, 2010·Nature Reviews. Genetics·Alkes L PriceNick Patterson
Oct 6, 2006·Bioinformatics·Thomas Hoffmann, Christoph Lange
Oct 15, 2008·Human Molecular Genetics·Chao TianMichael F Seldin
Aug 29, 2013·Molecular Human Reproduction·G W MontgomeryD R Nyholt
Oct 21, 2006·Current Opinion in Pulmonary Medicine·Michael R Knowles
Aug 24, 2010·Annals of Human Genetics·Tyler J VanderWeele, Nan M Laird
Mar 23, 2012·Genes, Brain, and Behavior·P PaschouM Grigoriou
Oct 22, 2008·Human Heredity·Yik Y TeoTaane G Clark
Dec 10, 2009·Human Heredity·Thomas J HoffmannNan M Laird
Aug 11, 2007·American Journal of Respiratory Cell and Molecular Biology·Dawn L DemeoEdwin K Silverman
Nov 14, 2012·Genetics, Selection, Evolution : GSE·Simon TeyssèdreAnne Ricard
Jun 3, 2009·Journal of Biomedical Science·Chen-Pang Lin, Cathy S J Fann
Jun 14, 2013·BMC Genomics·Satish KumarRichard K Volz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.