Family-Based Designs that Disentangle Inherited Factors from Pre- and Postnatal Environmental Exposures: In Vitro Fertilization, Discordant Sibling Pairs, Maternal versus Paternal Comparisons, and Adoption Designs.

Cold Spring Harbor Perspectives in Medicine
Anita Thapar, Frances Rice

Abstract

Identifying environmental risk and protective exposures that have causal effects on health is an important scientific goal. Many environmental exposures are nonrandomly allocated and influenced by dispositional factors including inherited ones. We review family-based designs that can separate the influence of environmental exposures from inherited influences shared between parent and offspring. We focus on prenatal exposures. We highlight that the family-based designs that can separate the prenatal environment from inherited confounds are different to those that are able to pull apart later-life environmental exposures from inherited confounds. We provide a brief review of the literature on maternal smoking during pregnancy and offspring attention-deficit/hyperactivity disorder (ADHD) and conduct problems; these inconsistencies in the literature make a review useful and this illustrates that results of family-based genetically informed studies are inconsistent with a causal interpretation for this exposure and these two offspring outcomes.

References

Jan 1, 1996·Archives of General Psychiatry·E SusserJ M Gorman
Jun 8, 2001·Psychological Bulletin·M RutterL Eaves
Mar 15, 2003·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Susan Golombok, Fiona MacCallum
Aug 4, 2005·JAMA : the Journal of the American Medical Association·David St ClairLin He
Dec 8, 2005·JAMA : the Journal of the American Medical Association·Risto J Kaaja, Ian A Greer
Feb 24, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Michael RutterAvshalom Caspi
Dec 21, 2006·Psychological Medicine·Kenneth S Kendler, Jessica H Baker
Jun 30, 2007·American Journal of Public Health·Stephen E GilmanKarestan C Koenen
Jul 26, 2008·American Journal of Epidemiology·Stephen E GilmanStephen L Buka
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Frances RiceAnita Thapar
Aug 4, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Anita Thapar, Michael Rutter
Apr 26, 2011·Journal of the American Academy of Child and Adolescent Psychiatry·Gemma LewisAnita Thapar
Feb 10, 2012·Epidemiology·George Davey Smith
Jul 12, 2012·Epidemiology·Thomas FrisellArvid Sjölander
Apr 4, 2013·Epidemiology·Katherine M KeyesEzra Susser
Jul 26, 2013·JAMA Psychiatry·Theodore A Slotkin
Nov 2, 2014·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Charlotte SkoglundHenrik Larsson
Nov 22, 2014·European Child & Adolescent Psychiatry·Viviane KovessEzra Susser
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Kenneth S KendlerKristina Sundquist
Oct 8, 2015·Annual Review of Psychology·Suzanne H GageGeorge Davey Smith
Oct 30, 2015·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Carsten ObelMichael Rutter
Nov 15, 2016·The American Journal of Psychiatry·Kieran J O'Donnell, Michael J Meaney
Jan 22, 2017·International Journal of Epidemiology·Debbie A LawlorGeorge Davey Smith
Feb 1, 2017·Pediatrics·Kristin GustavsonTed Reichborn-Kjennerud
Apr 14, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Mikael EkbladMika Gissler
Jul 1, 2017·Journal of Abnormal Child Psychology·Kristine MarceauValerie S Knopik
Aug 17, 2017·Current Opinion in Psychology·Susan Golombok
Aug 30, 2017·Neuroscience and Biobehavioral Reviews·I Hyun RuischPieter J Hoekstra
Nov 1, 2017·International Journal of Epidemiology·Eleanor SandersonGeorge Davey Smith
Jan 27, 2018·Science·Augustine KongKari Stefansson

❮ Previous
Next ❯

Citations

Sep 18, 2020·Journal of Autism and Developmental Disorders·Anita Thapar, Michael Rutter
Mar 24, 2021·Cold Spring Harbor Perspectives in Medicine·Kate E Lynch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.