Family discord, parental depression, and psychopathology in offspring: ten-year follow-up

Journal of the American Academy of Child and Adolescent Psychiatry
Yoko NomuraMyrna M Weissman

Abstract

To determine the independent effects of parental depression and family discord on psychopathology in offspring at high and low risk for major depression. One hundred eighty-two offspring of depressed or nondepressed parents were followed over 10 years. In direct interviews, parents' and offspring's psychopathology was evaluated by raters blind to parents' clinical status. Five dimensions of family discord-poor marital adjustment, parent-child discord, low family cohesion, affectionless control, and parental divorce-were assessed. Offspring exposed to either parental depression or family discord had higher rates of psychopathology than their counterparts. High-risk offspring had few family discord measures associated with their psychopathology; in low-risk offspring, family discord was associated with all offspring diagnoses. Between the two risk factors, parental depression proved a more important predictor for offspring major depressive disorder (MDD) and anxiety disorder, whereas family discord was a more important predictor for substance use disorder. Parental depression is a strong and consistent risk factor for offspring MDD and anxiety disorder. Without parental depression, offspring have less exposure to family discord a...Continue Reading

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References

Jul 1, 1990·Psychological Bulletin·G Downey, J C Coyne
Jun 1, 1987·The American Journal of Psychiatry·C HammenD Hiroto
Aug 1, 1982·Archives of General Psychiatry·J F LeckmanM M Weissman
Dec 1, 1982·Archives of General Psychiatry·M M WeissmanB A Prusoff
Nov 1, 1981·Archives of General Psychiatry·M M WeissmanK John
Jul 1, 1993·Journal of the American Academy of Child and Adolescent Psychiatry·W R BeardsleeN Sacks
Oct 1, 1995·Journal of Child Psychology and Psychiatry, and Allied Disciplines·D M FergussonM T Lynskey
Oct 24, 1997·Archives of General Psychiatry·M M WeissmanM Olfson
Nov 11, 1998·Journal of the American Academy of Child and Adolescent Psychiatry·W R BeardsleeT R Gladstone
Nov 18, 2000·Journal of Child Psychology and Psychiatry, and Allied Disciplines·B L BakerB Henker
Mar 14, 2001·Journal of Affective Disorders·Y MinoS Kanazawa

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Citations

Mar 10, 2010·European Child & Adolescent Psychiatry·Christine M FreitagMarcel Romanos
Sep 10, 2005·Clinical Child and Family Psychology Review·Janay B Sander, Carolyn A McCarty
Feb 4, 2011·Clinical Child and Family Psychology Review·John D Guerry, Paul D Hastings
Nov 26, 2011·Clinical Child and Family Psychology Review·Ronald M Rapee
Jan 14, 2012·Clinical Child and Family Psychology Review·Kelly L Drake, Golda S Ginsburg
Mar 7, 2012·Child Psychiatry and Human Development·Cliff McKinney, Mary Catherine Milone
Jan 22, 2009·Maternal and Child Health Journal·Michael SilversteinWilliam Beardslee
Jul 2, 2011·Indian Pediatrics·Rajesh SagarManju Mehta
Feb 13, 2004·Biological Psychiatry·Sarah L HalliganLynne Murray
Apr 17, 2003·Epilepsy & Behavior : E&B·David W Dunn
Jul 29, 2004·Journal of Consulting and Clinical Psychology·Constance HammenPatricia A Brennan
Jun 17, 2009·The Australian and New Zealand Journal of Psychiatry·Jun Ping HuangLi Jie Wu
Jul 31, 2012·European Journal of Public Health·Danielle E M C JansenSijmen A Reijneveld
Dec 4, 2009·Journal of Pediatric Psychology·Karli TreyvaudPeter J Anderson
Apr 14, 2005·Journal of Developmental and Behavioral Pediatrics : JDBP·Maureen HackElaine Borawski
May 5, 2005·The Journal of Nervous and Mental Disease·Merav GurMyrna Weissman
Dec 17, 2009·The Journal of Nervous and Mental Disease·Dana LizardiDeborah Hasin
Feb 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J John Mann
Dec 17, 2009·Health and Quality of Life Outcomes·George GiannakopoulosYannis Tountas
Aug 20, 2011·Croatian Medical Journal·Sanja Smojver-Azić, Petar Bezinović
Oct 14, 2009·European Child & Adolescent Psychiatry·Floor V A van OortAnja C Huizink
May 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Scott WeichSarah Stewart-Brown
Feb 3, 2016·Journal of Youth and Adolescence·Rachel D FreedLauren B Alloy
Sep 1, 2015·Hormones and Behavior·Susanne Brummelte, Liisa A M Galea
Jul 25, 2012·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Todd I HerrenkohlJ David Hawkins
Dec 16, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·Michael Rutter
Oct 24, 2009·Physiology & Behavior·Brittany M NavarreRebecca M Craft
Sep 16, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Brummelte, Liisa A M Galea
Feb 3, 2009·Journal of the American Academy of Child and Adolescent Psychiatry·Angela D ParadisGarrett M Fitzmaurice
Apr 10, 2009·Clinical Psychology Review·Kathleen Restifo, Susan Bögels
Mar 22, 2008·Journal of the American Academy of Child and Adolescent Psychiatry·Laura J DietzNeal D Ryan
Feb 27, 2008·Journal of Affective Disorders·Holly C WilcoxGerald Nestadt
Dec 1, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Boris BirmaherJennifer Medicus

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