Abstract
Adult-onset, chronic, genetic diseases like transthyretin-related familial amyloid polyneuropathy Val30Met (TTR-FAP Val30Met), have a major psychosocial impact not only on patients, but also on families. Genetic risk may therefore be an increased factor in psychosocial impact of the disease on these families' functioning. To evaluate impact of genetic risk, a study was conducted to perceive the impact of the illness on families' functioning. Groups of TTR-FAP Val30Met patients, pre-symptomatic carriers, partners and patients with multiple sclerosis (MS), a non-hereditary disease, were studied. Sample included 190 adults: 87 patients and 28 pre-symptomatic carriers for TTR-FAP Val30Met, 41 partners and 34 patients with MS. Family Adaptability and Cohesion Scale IV (FACES IV) and a social-demographic questionnaire were applied. No significant differences were observed between patients and pre-symptomatic carriers and both these and their partners regarding cohesion and flexibility. MS patients scored significantly higher in median scores for balanced scales. Satisfaction and communication levels were also lower in patients with TTR-FAP Val30Met than with MS. Family functioning was perceived as balanced by most TTR-FAP Val30Met pa...Continue Reading
References
Mar 1, 1979·Family Process·D H OlsonC S Russell
Jun 1, 1987·Family Process·J S Rolland
Sep 1, 1986·Family Process·D H Olson
Sep 1, 1993·Human Heredity·A SousaO Sandgren
Dec 18, 1995·American Journal of Medical Genetics·A SousaJ Sequeiros
Feb 15, 2000·Journal of Advanced Nursing·E JonsénO B Suhr
Feb 1, 2003·Science·Per HammarströmJeffery W Kelly
Mar 5, 2003·Family Process·A Christine Brouwer-DudokdewitAad Tibben
Apr 18, 2003·Family Process·Froma Walsh
Apr 18, 2003·Family Process·Susan Sobel, C Brookes Cowan
Apr 6, 2005·Family Process·John S Rolland, Janet K Williams
Apr 6, 2005·Family Process·Susan H McDaniel
Sep 14, 2006·Muscle & Nerve·Isabel Conceição, Mamede De Carvalho
Jun 8, 2007·Muscle & Nerve·Merrill D Benson, John C Kincaid
Sep 20, 2007·Psychosomatics·Marina VamosJohn Conaghan
Jan 5, 2011·Journal of Marital and Family Therapy·David Olson
Jan 10, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Haruki KoikeGen Sobue
Apr 5, 2012·Current Medicinal Chemistry·Y Ando, M Ueda
May 31, 2012·Proceedings of the National Academy of Sciences of the United States of America·Christine E BulawaRichard Labaudinière
Aug 27, 2013·Journal of Neurology·Teresa CoelhoDonna R Grogan
Jan 9, 2015·Journal of the American Board of Family Medicine : JABFM·Kieran Walsh
Aug 27, 2015·Transplantation·Bo-Göran EriczonOle Suhr
Dec 22, 2015·Psychiatria polska·Jan Domaradzki
Jan 7, 2016·Current Opinion in Neurology·Yesim ParmanUNKNOWN from the European Network for TTR-FAP (ATTReuNET)
Jan 7, 2016·Current Opinion in Neurology·David AdamsUNKNOWN from the European Network for TTR-FAP (ATTReuNET)
Mar 23, 2017·European Journal of Human Genetics : EJHG·Carla Roma OliveiraLiliana Sousa
Jul 18, 2017·Family Process·Álvaro MendesJorge Sequeiros
Oct 21, 2017·Journal of Community Genetics·Alice LopesPaula Freitas