Family history and risk of type 1 diabetes mellitus

Acta Diabetologica
S SipetićL Denić

Abstract

The aim of the study was to evaluate association of type 1 diabetes in children and adolescents with positive family history of type 1 diabetes, type 2 diabetes, and thyroid, adrenal, rheumatic, allergic, celiac and some other diseases. A case-control study was conducted in Belgrade. The case group comprised 105 subjects < or = 16 years old who were for the first time hospitalized because of type 1 diabetes during the period 1994-1997. For each case, two controls were chosen among children and adolescents treated for skin diseases. Cases and controls were individually matched by age (+/- one year), sex and place of residence (all were from Belgrade). In the statistical analyses we used chi(2)-test, Fisher's exact test and univariate and multivariate logistic regressions. According to multivariate logistic regression analysis, risk of type 1 diabetes was significantly associated with a positive family history for type 1 diabetes (OR = 4.04; 95% CI, 2.31-7.07), allergic diseases (OR = 3.32; 95% CI, 1.63-6.76), celiac and Crohn's diseases (OR = 11.02; 95% CI, 1.14-106.89) and other diseases (thrombocytopenia, alopecia areata, psoriasis, chronic uveitis and pernicious anemia; OR = 3.63; 95% CI, 1.05-12.48).

Citations

Apr 11, 2009·Archives of Dermatological Research·Vladimir VaskuAnna Vasku
Mar 24, 2005·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Mohamed A A MoussaJoseph E Gomez
Oct 4, 2012·Diabetes Care·Anna ParkkolaUNKNOWN Finnish Pediatric Diabetes Register
May 24, 2013·European Journal of Endocrinology·Anna ParkkolaUNKNOWN Finnish Pediatric Diabetes Register
May 28, 2011·Journal of the American Academy of Dermatology·Szu-Ying ChuHan-Nan Liu
Sep 22, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·C GohA A Sinha
Aug 28, 2004·Primary Care·Astrid M Newell
Nov 20, 2012·Dermatologic Clinics·Ali JabbariAngela M Christiano
Jan 23, 2014·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Tanja MaasJan G Damoiseaux
Jan 17, 2008·Diabetes·Hubert TsuiHans-Michael Dosch
Oct 16, 2014·Autoimmunity Reviews·Naseeha IslamM Eric Gershwin
Oct 4, 2016·Medical Hypotheses·J Jaime MirandaRicardo Roman-Carpio
Apr 4, 2003·Diabetes/metabolism Research and Reviews
Aug 15, 2013·International Journal of Molecular Medicine·Carmen HärdtnerUwe Lendeckel
Jun 18, 2014·Frontiers in Endocrinology·Grace C DaveyTimothy O'Brien
Jul 31, 2018·Frontiers in Medicine·Rita BottinoMassimo M Trucco
May 15, 2010·Annals of Medicine·Tapio SeiskariHeikki Hyöty
Dec 18, 2020·Diabetologia·Anna ParkkolaUNKNOWN Finnish Pediatric Diabetes Register
Jul 22, 2018·Journal of the American Academy of Dermatology·Solam LeeWon-Soo Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.