Family history and the risk of prostatic carcinoma in a high risk group of urological patients

The Journal of Urology
A G AprikianS Narod

Abstract

We examine the association of family history and prostatic carcinoma. A total of 2,968 consecutive patients referred for prostate cancer detection responded to a questionnaire and underwent transrectal ultrasound examination with or without biopsy. Of the men 329 (11.1%) had a family history of prostate cancer. No differences were observed between groups with and without a family history with respect to mean patient age, serum prostate specific antigen level or biopsy rate. Prostate cancer was detected in 133 of 329 patients (40.4%) with a family history and 769 of 2,639 (29.1) with no family history (p < 0.001, odds ratio 1.7). No significant differences were observed between cancer patients with or without a family history with respect to mean Gleason score (6.0 versus 6.2), patient age at diagnosis (65.8 versus 66.7) and prostate specific antigen level (16.8 versus 17.1). Patients with a family history of prostate cancer have a greater risk of the disease. In this select group of patients a positive family history was not associated with an earlier age at cancer diagnosis or a different histological grade of tumor.

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·B S CarterP C Walsh
Nov 1, 1991·The Journal of Urology·M R SpitzG R Newell
Jan 1, 1990·The Prostate·G D SteinbergP C Walsh
Sep 1, 1993·The Journal of Urology·B S CarterP C Walsh

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Citations

Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·E SpanglerT R Rebbeck
Mar 7, 2006·The Journal of Urology·Stijn RoemelingFritz H Schröder
Nov 9, 2000·Urology·L A KalishJ B McKinlay
Sep 8, 1998·Urology·F E GloverP C Walsh
Dec 14, 2011·The Cancer Journal·Mark M Pomerantz, Matthew L Freedman
Apr 1, 1997·British Journal of Urology·P EkmanJ Dich
Aug 21, 2002·The Journal of Urology·Ola Bratt
Nov 26, 2010·The Mount Sinai Journal of Medicine, New York·Mark M Pomerantz, Matthew L Freedman
Nov 4, 2010·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Wade J SextonPatricia Troncoso
Jul 24, 2004·Urologic Oncology·Jeffrey B MarotteJoseph C Presti
Oct 21, 2003·International Journal of Cancer. Journal International Du Cancer·Deborah Watkins BrunerPaul Engstrom
Jul 8, 2011·The Cochrane Database of Systematic Reviews·Frank PeinemannStefan Sauerland
Feb 24, 2011·Korean journal of urology·Seung Hwan LeeByung Ha Chung
Jun 1, 1996·The Journal of Urology·D W KeetchW J Catalona
May 5, 2021·Investigative and Clinical Urology·Sang Hun Song, Seok Soo Byun

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