Family history does not predict angiographic localization or severity of coronary artery disease.

Atherosclerosis
Amitava BanerjeePeter M Rothwell

Abstract

Family history of MI is an established risk factor for coronary artery disease and subclinical atherosclerosis. Maternal MI and maternal stroke are more common in females than males presenting with acute coronary syndromes (ACS), suggesting sex-specific heritability, but the effects of family history on location and extent of coronary artery disease are unknown. In a prospective, population-based study (Oxford Vascular Study) of all patients with ACS, family history data for stroke and MI were analysed by sex of proband and affected first degree relatives (FDRs), and coronary angiograms were reviewed, where available. Of 835 probands with one or more ACS, 623 (420 males) had incident events and complete family history data. 351 patients with incident events (56.3%; 266 males) underwent coronary angiography. Neither angiographic disease localization nor severity were associated with sex-of-parent/sex-of-offspring in men or women. Sex-specific family history data do not predict angiographic localization of coronary disease in patients presenting with ACS. Maternal stroke and maternal MI probably affect ACS in females by a mechanism unrelated to atherosclerosis or coronary anatomy. However, family history data may still be useful ...Continue Reading

References

May 1, 1991·The American Journal of Cardiology·G A ColditzW C Willett
Jul 1, 1969·Journal of Electrocardiology·H Blackburn
Feb 1, 1983·The American Journal of Cardiology·G G Gensini
Dec 11, 1993·BMJ : British Medical Journal·F KeeF Cambien
May 1, 1996·Journal of Clinical Epidemiology·P JousilahtiJ Tuomilehto
Mar 31, 1998·European Heart Journal·S Pohjola-SintonenK Luomanmäki
Mar 17, 2004·Annals of Internal Medicine·Joanne M MurabitoPeter W F Wilson
May 18, 2004·Heart·K A A FoxUNKNOWN British Cardiac Society Working Group
Dec 24, 2004·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Myriam FornageEric Boerwinkle
Oct 12, 2005·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Manfredi RizzoMaurizio R Averna
Jan 24, 2007·Lancet Neurology·Emmanuel Touzé, Peter M Rothwell
Apr 28, 2007·International Journal of Cardiology·Javier PinedaFrancisco Sogorb
Jun 3, 2008·American Heart Journal·Catalin TaraboantaJiri Frohlich
Feb 21, 2009·The New England Journal of Medicine·Patrick W SerruysUNKNOWN SYNTAX Investigators
Mar 12, 2009·European Heart Journal·Franz WiesbauerMartin Schillinger
Mar 25, 2009·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ted Feldman
Jul 7, 2009·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Keith D DawkinsPatrick W Serruys
Dec 25, 2009·Circulation. Cardiovascular Genetics·Amitava BanerjeePeter M Rothwell
Jan 29, 2011·Journal of the American College of Cardiology·Clara K ChowSalim Yusuf
Feb 4, 2011·Circulation. Cardiovascular Genetics·Amitava BanerjeePeter M Rothwell

❮ Previous
Next ❯

Citations

May 3, 2014·Archives of Cardiovascular Diseases·Laurent LariflaLydia Foucan
May 14, 2016·International Journal for Numerical Methods in Biomedical Engineering·C A BulantP A Lemos
Oct 14, 2018·Journal of Cardiovascular Translational Research·Yong LiuJiyan Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.