Family history of Alzheimer's disease limits improvement in cognitive function after bariatric surgery

SAGE Open Medicine
Michael L AloscoJohn Gunstad

Abstract

Bariatric surgery can reverse cognitive impairments associated with obesity. However, such benefits may be attenuated in individuals with a predisposing risk for cognitive impairment such as family history of Alzheimer's disease. In all, 94 bariatric surgery participants completed a computerized cognitive test battery before and 12 weeks after surgery. Family history of Alzheimer's disease was obtained through self-report. In the overall sample, cognitive function improved in memory and attention/executive function 12 weeks post-surgery. Repeated measures showed similar rates of improvements in attention/executive function between patients with and without a family history of Alzheimer's disease. In contrast, only individuals without a family history of Alzheimer's disease exhibited post-operative improvements in memory. A family history of Alzheimer's disease was associated with greater post-surgery rates of cognitive impairment. Family history of Alzheimer's disease may limit post-surgery cognitive benefits. Future studies should examine whether weight loss can modify the course of cognitive decline in patients at-risk for Alzheimer's disease.

References

Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
May 20, 2000·Annals of the New York Academy of Sciences·J S MeyerK Crawford
Oct 15, 2005·The International Journal of Neuroscience·Robert H PaulEvian Gordon
Nov 17, 2005·The International Journal of Neuroscience·L M WilliamsE Gordon
Aug 9, 2006·Archives of General Psychiatry·Matthias H TabertD P Devanand
Oct 10, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Martin Wilhelm KurzDag Aarsland
Mar 28, 2007·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Steven H BelleUNKNOWN Longitudinal Assessment of Bariatric Surgery Consortium Writing Group
Jul 1, 2008·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·David B SarwerNoel N Williams
Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Lisa MosconiMony J de Leon
Aug 6, 2010·The American Journal of Psychiatry·Markus DonixSusan Y Bookheimer
Aug 18, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Barbara B BendlinSterling C Johnson
Dec 15, 2010·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·John GunstadJames E Mitchell
Feb 24, 2012·Neuropsychology Review·Markus DonixSusan Y Bookheimer
Jul 21, 2012·Dementia and Geriatric Cognitive Disorders·Adina Zeki Al HazzouriJohn Neuhaus
Mar 27, 2013·Neuropsychology·Kelly M StanekJohn Gunstad
Mar 28, 2013·Current Pharmaceutical Design·Vanessa V Dos SantosRui D Prediger
Apr 23, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Katherine J BangenRhoda Au
May 3, 2013·Obesity Surgery·Lindsay A MillerJohn Gunstad
Oct 15, 2013·American Journal of Surgery·Michael L AloscoJohn Gunstad
Oct 24, 2013·World Journal of Gastroenterology : WJG·Marco MiloneMario Musella
Nov 26, 2013·Neurobiology of Aging·Sterling C JohnsonMark A Sager

❮ Previous
Next ❯

Citations

Jul 30, 2016·Obesity Surgery·Joel D HandleyJonathan Barry
Jan 6, 2018·Journal of Occupational and Environmental Medicine·Charles M YarboroughJulie Ording
Feb 23, 2019·Journal of Nutrition in Gerontology and Geriatrics·Robert M RothJohn A Batsis
Aug 21, 2015·European Eating Disorders Review : the Journal of the Eating Disorders Association·Mary Beth SpitznagelJohn Gunstad
Sep 12, 2017·The Proceedings of the Nutrition Society·Louise DyeClare Lawton

❮ Previous
Next ❯

Methods Mentioned

BETA
gastric bypass

Software Mentioned

IntegNeuro

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
Rachel GaliotoJohn Gunstad
Annals of Surgery
Didier QuilliotLaurent Brunaud
© 2022 Meta ULC. All rights reserved