Family history of cardiovascular disease and risk of premature coronary heart disease: A matched case-control study.

Wellcome Open Research
Manas ChackoPanniyammakal Jeemon

Abstract

Background: Self-reported family history of cardiovascular disease (CVD) is an independent risk factor for future coronary heart disease (CHD) events. However, inclusion of family history of CVD in the traditional risk scores failed to improve risk prediction of CHD. It is proposed that family history of CVD may substantially increase the risk of CHD among younger individuals. Methods: We conducted a matched case-control study with 170 hospital-based premature CHD patients (<55 years in men and <65 years in women) from a tertiary care centre in Thiruvananthapuram, Kerala and age and sex matched community-based controls in 1:1 ratio. Conditional logistic regression analysis was conducted to assess the independent association of family history of cardiovascular disease (CVD) and premature CHD. We estimated McNemar's odds ratios and their 95 percent confidence intervals. Results: The prevalence of any family history of CVD and CHD in the control population was 24% and 21%, respectively. The family history of CVD was independently associated with premature CHD (odds ratio (OR) = 9.0; 95% confidence interval (CI) 4.7-17.3). There was a dose-response relationship between family history and premature CHD as the risk increased linearly...Continue Reading

References

Feb 20, 2003·European Heart Journal·J De SutterUNKNOWN EUROpean Action on Secondary Prevention through Intervention to Reduce Events II study group
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Jan 18, 2007·JAMA : the Journal of the American Medical Association·Prashant JoshiSalim Yusuf
Feb 15, 2007·JAMA : the Journal of the American Medical Association·Paul M RidkerNancy R Cook
Jun 25, 2008·BMJ : British Medical Journal·Julia Hippisley-CoxPeter Brindle
Jan 29, 2011·Journal of the American College of Cardiology·Clara K ChowSalim Yusuf
Dec 15, 2012·The Mount Sinai Journal of Medicine, New York·Dorairaj Prabhakaran, Panniyammakal Jeemon
Jul 3, 2013·Indian Heart Journal·Geevar ZachariahUNKNOWN Cardiological Society of India Kerala Chapter Coronary Artery Disease and Its Risk Factors Prevalence (CSI Kerala CRP) Study
Apr 23, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Waseem HindiehUNKNOWN PRAXY Investigators*
May 5, 2016·Circulation·Dorairaj PrabhakaranAmbuj Roy
Dec 14, 2016·The New England Journal of Medicine·Amit V KheraSekar Kathiresan
Sep 17, 2018·The Lancet Global Health·UNKNOWN India State-Level Disease Burden Initiative CVD Collaborators

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Citations

Nov 9, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Kaveh HosseiniMasih Tajdini

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