PMID: 16634470Apr 26, 2006Paper

Family history of dementia does not influence the progression of Alzheimer's disease at two years: results from the REAL.FR Study

American Journal of Alzheimer's Disease and Other Dementias
F CortesBruno Vellas

Abstract

The purpose of this study was to determine whether a family history of dementia in a first-degree relative influenced the progression of Alzheimer's disease (AD) after two years of follow-up. Patients were recruited in the REAL.FR (Réseau sur la Maladie d'Alzheimer Français) study and underwent behavioral, global, nutritional, and medical evaluation with assessment of cognitive function and independence every six months. At inclusion, 113 patients reported a family history of dementia, and 358 patients had no family history of dementia. There was no statistical difference for any factors between the two groups at baseline. After two years of follow-up, a similar percentage of patients were still followed in each group, and although most parameters showed significant deterioration, there was no difference between the two groups, indicating that a family history of dementia does not appear to influence the progression of AD.

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Citations

Oct 6, 2010·The Journal of Nutrition, Health & Aging·J MauskopfE Sherrill
Jan 16, 2014·International Review of Psychiatry·Alessandro SonaDavid Ames
Oct 15, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Renaud DavidJamie M Zeitzer
Jun 15, 2007·La Presse médicale·Maria SotoBruno Vellas
Jan 19, 2021·Journal of Alzheimer's Disease : JAD·David A Loeffler

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