Family history of prostate cancer in patients with localized prostate cancer: an independent predictor of treatment outcome

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Patrick A KupelianEric A Klein

Abstract

To determine if familial prostate cancer patients have a less favorable prognosis than patients with sporadic prostate cancer after treatment for localized disease with either radiotherapy (RT) or radical prostatectomy (RP). One thousand thirty-eight patients treated with either RT (n = 583) or RP (n = 455) were included in this analysis. These patients were noted as having a positive family history if they confirmed the diagnosis of prostate cancer in a first-degree relative. The outcome of interest was biochemical relapse-free survival (bRFS). We used proportional hazards to analyze the effect of the presence of family history and other potential confounding variables (ie, age, treatment modality, stage, biopsy Gleason sum [GS], and initial prostate-specific antigen [iPSA] levels) on treatment outcome. Eleven percent of all patients had a positive family history. The 5-year bRFS rates for patients with negative and positive family histories were 52% and 29%, respectively (P < .001). The potential confounders with bRFS rates were iPSA levels, biopsy GS, and clinical tumor stage; treatment modality and age did not appear to be associated with outcome. After adjusting for potential confounders, family history of prostate cancer ...Continue Reading

Citations

May 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Benjamin A SpencerMark S Litwin
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·E SpanglerT R Rebbeck
Jan 26, 2006·Human Molecular Genetics·Graham CaseyJohn S Witte
Mar 7, 2006·The Journal of Urology·Stijn RoemelingFritz H Schröder
Apr 9, 2011·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Milan KralJan Bouchal
May 12, 2015·CA: a Cancer Journal for Clinicians·Christopher P FilsonMark S Litwin
Jun 2, 2016·Journal of Korean Medical Science·Hyung Kyu ParkHye Seung Han
Jul 22, 1998·Journal of the National Cancer Institute·N M Lindor, M H Greene
Nov 7, 2006·The Journal of Urology·Kimberly A RoehlWilliam J Catalona
Jul 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick A KupelianEric A Klein
Nov 7, 1998·British Journal of Urology·H GrönbergJ E Damber
Nov 25, 2003·BJU International·B J EldonH Tulinius
Apr 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kari HemminkiPer Lenner
Sep 30, 2010·Acta Oncologica·Giuseppe Colloca, Antonella Venturino
Apr 22, 2011·BJU International·Sanna PakkanenTeuvo L J Tammela
Mar 13, 2016·BJU International·Christina G Selkirk, Brian T Helfand
Mar 29, 2000·BJU International·O Bratt
Oct 14, 2006·Current Opinion in Urology·J E Damber
Nov 4, 2010·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Wade J SextonPatricia Troncoso
Nov 20, 1997·The Journal of Urology·P A KupelianJ H Suh
Jan 25, 2021·Familial Cancer·Holly Ni Raghallaigh, Rosalind Eeles

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