Family Member Deaths in Childhood Predict Systemic Inflammation in Late Life

Biodemography and Social Biology
Maria C NortonKen Smith

Abstract

Biological and epidemiological evidence has linked early-life psychosocial stress with late-life health, with inflammation as a potential mechanism. We report here the association between familial death in childhood and adulthood and increased levels of high-sensitivity C-reactive protein (CRP), a marker of systemic inflammation. The Cache County Memory Study is a prospective study of persons initially aged 65 and older in 1995. In 2002, there were 1,955 persons in the study with data on CRP (42.3 percent male, mean [SD] age = 81.2 [5.8] years), linked with objective data on family member deaths. Using logistic regression, high (> 10 mg/L) versus low (≤ 10 mg/L) CRP was regressed on cumulative parental, sibling, spouse, and offspring deaths during childhood and during early adulthood, adjusted for family size in each period (percentage family depletion; PFD). Findings revealed PFD during childhood to be significantly associated with CRP (OR = 1.02, 95% CI [1.01, 1.04]). Individuals with two or more family deaths were 79 percent more likely to have elevated CRP than those with zero family deaths (OR = 1.79, 95% CI [1.07, 2.99]). Early adulthood PFD was not related to CRP. This study demonstrates a link between significant psycho...Continue Reading

References

Dec 1, 1981·Journal of Health and Social Behavior·L I PearlinJ T Mullan
Feb 11, 2000·Neurology·V M MoceriE B Larson
Apr 15, 2005·The New England Journal of Medicine·Steven Woloshin, Lisa M Schwartz
Jun 15, 2007·Neurology·R S WilsonD A Bennett
Sep 1, 1983·Biotechnology and Bioengineering·N S Wang, G Stephanopoulos
Aug 12, 2009·International Journal of Nursing Studies·Thomas BuckleyRoger Bartrop
Sep 11, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marta KuberaMichael Maes
Mar 15, 2011·Medical Hypotheses·Daniel A NationJoel E Dimsdale
May 4, 2011·Psychosomatic Medicine·Allison A AppletonLaura D Kubzansky
May 27, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ioannis SotiropoulosOsborne F X Almeida
Jul 21, 2011·Mediators of Inflammation·Hongliang ZhangJiang Wu
Aug 30, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Maria C NortonUNKNOWN Cache County Investigators
Apr 5, 2012·Nature Reviews. Cardiology·Andrew Steptoe, Mika Kivimäki
Jun 28, 2012·Brain, Behavior, and Immunity·Christian R Schultze-FloreyMary-Frances O'Connor
Jul 24, 2012·International Journal of Geriatric Psychiatry·Lawrence J WhalleyJohn M Starr
Dec 25, 2012·Brain, Behavior, and Immunity·Masaaki IwataRonald S Duman
Dec 26, 2012·JAMA Psychiatry·Marie Kim Wium-AndersenBørge Grønne Nordestgaard
Jan 16, 2013·Journal of Cardiovascular Pharmacology·Xiao-Ting LuFan Jiang
Aug 21, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Daylee GreeneUNKNOWN Cache County Investigators
Feb 18, 2014·Social Science & Medicine·Ken R SmithGeraldine P Mineau
May 7, 2014·International Journal of Geriatric Psychiatry·Daniel J HatchMaria C Norton

❮ Previous
Next ❯

Citations

Apr 24, 2020·PloS One·James VanDersliceDeborah W Neklason
May 12, 2020·International Journal of Geriatric Psychiatry·Josep L Conde-Sala, Josep Garre-Olmo
Dec 14, 2019·European Journal of Population = Revue Européenne De Démographie·Ingrid K van DijkKen R Smith

❮ Previous
Next ❯

Methods Mentioned

BETA
blood collection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Daniel RamirezSami L Bahna
© 2022 Meta ULC. All rights reserved