Family members of patients with abdominal aortic aneurysms are at increased risk for aneurysms: analysis of 618 probands and their families from the Liège AAA Family Study

Annals of Vascular Surgery
Natzi SakalihasanHelena Kuivaniemi

Abstract

The objectives were to answer the following questions with the help of a well-characterized population in Liège, Belgium: 1) what percentage of patients with abdominal aortic aneurysm (AAA) have a positive family history for AAA? 2) what is the prevalence of AAAs among relatives of patients with AAA? and 3) do familial and sporadic AAA cases differ in clinical characteristics? Patients with unrelated AAA diagnosed at the Cardiovascular Surgery Department, University Hospital of Liège, Belgium, between 1999 and 2012 were invited to the study. A detailed family history was obtained in interviews and recorded using Progeny software. We divided the 618 patients into 2 study groups: group I, 296 patients with AAA (268; 91% men) were followed up with computerized tomography combined with positron emission tomography; and group II, 322 patients with AAA (295; 92% men) whose families were invited to ultrasonographic screening. In the initial interview, 62 (10%) of the 618 patients with AAA reported a positive family history for AAA. Ultrasonographic screening identified 24 new AAAs among 186 relatives (≥50 years) of 144 families yielding a prevalence of 13%. The highest prevalence (25%) was found among brothers. By combining the number...Continue Reading

References

Nov 1, 1977·The British Journal of Surgery·M A Clifton
Nov 1, 1992·The British Journal of Surgery·H BengtssonD Bergqvist
Sep 1, 1992·The British Journal of Surgery·J AdamsonR M Greenhalgh
Oct 7, 1989·BMJ : British Medical Journal·H J Scott, T R Cheatle
Apr 1, 1984·American Journal of Surgery·M D Tilson, M R Seashore
Aug 1, 1995·Australasian Radiology·G LarcosJ P Fletcher
Apr 1, 1995·The British Journal of Surgery·P FitzgeraldD Bouchier-Hayes
Jul 17, 1998·The British Journal of Surgery·Y van der GraafB C Eikelboom
Oct 24, 1998·Journal of Vascular Surgery·P F LawrenceL Kraiss
Apr 24, 1999·Annals of Internal Medicine·J A SaloP S Mattila
May 5, 2001·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·J I RossaakA M van Rij
Jul 4, 2001·Journal of Vascular Surgery·F A LederleUNKNOWN Aneurysm Detection and Management Veterans Affairs Cooperative Study
May 25, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·N SakalihasanR Limet
Feb 4, 2003·Journal of Vascular Surgery·Helena KuivaniemiGerard Tromp
May 4, 2005·Lancet·N SakalihasanO D Defawe
May 2, 2007·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S A BadgerC V Soong
Nov 26, 2008·Journal of Vascular Surgery·Emma LarssonRebecka Hultgren
Nov 21, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·X Y XuN Sakalihasan
Nov 27, 2009·Journal of Vascular Surgery·Carl Magnus WahlgrenJesper Swedenborg
Dec 15, 2010·Annals of Vascular Surgery·Irene HinterseherHelena Kuivaniemi
Sep 9, 2011·Circulation·Frank A Lederle
Sep 7, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Audrey CourtoisNatzi Sakalihasan

❮ Previous
Next ❯

Citations

May 17, 2014·Scientifica·Helena KuivaniemiGerard Tromp
Aug 12, 2014·Annals of Vascular Surgery·Georgios MakrygiannisNatzi Sakalihasan
Aug 27, 2015·Expert Review of Cardiovascular Therapy·Helena KuivaniemiGerard Tromp
Jan 20, 2017·Nature Reviews. Cardiology·Aline VerstraetenBart Loeys
Mar 23, 2017·Scandinavian Cardiovascular Journal : SCJ·Anneli LinnéRebecka Hultgren
Sep 28, 2017·Journal of Cardiovascular Pharmacology·Shi-Lan ZhangLing Liu
Feb 1, 2019·The British Journal of Surgery·R HultgrenS Svensjö
May 10, 2018·Angiology·Georgios MakrygiannisAthanasios Giannoukas
Apr 30, 2017·PloS One·Antoni Sisó-AlmirallJaume Benavent Àreu
Oct 20, 2018·Nature Reviews. Disease Primers·Natzi SakalihasanRebecka Hultgren
Jun 1, 2018·Oxidative Medicine and Cellular Longevity·Jingyuan SunLing Gao
Oct 17, 2017·Annals of Vascular Diseases·Mitsunori NakanoHideo Adachi
Sep 4, 2020·International Journal of Molecular Sciences·Rijan GurungVitaly Sorokin
Aug 2, 2018·Journal of Vascular Surgery·Evan J RyerJames R Elmore

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Cardiac Aneurysm

Aneurysm refers to a bulge of the wall or lining of a vessel commonly occurring in the blood vessels at the base of the septum or within the aorta. In the heart, it usually arises from a patch of weakened tissue in a ventricular wall, which swells into a bubble filled with blood. Discover the latest research on cardiac aneurysm here.

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.