Family studies of neutrophil alloantigens in bone marrow transplantation

Tissue Antigens
B SchacterS Gross

Abstract

In order to evaluate the utility of the neutrophil specific antigens NA1, NA2, Vaz (NC1), NB1 and 9a in the documentation of bone marrow chimeras in recipients of allogeneic bone marrow grafts, neutrophil antigen typing was performed by EDTA microagglutination on the families of 17 patients with hematopoietic disorders under evaluation for bone marrow transplantation. Mendelian segregation independent of HLA and mutually independent was noted for the NA, NB and 9a systems. Vaz (NC1) segregated with and was included in NA2. Serological complexity was noted for NA1 and NA2. Typing for neutrophil antigens was achieved for 13 of 17 patients. Eight of 10 patients with HLA identical siblings had neutrophil antigen markers differing between donor and recipient. Conversion to donor neutrophil phenotype was documented for four recipients of bone marrow grafts. The neutrophil antigens, particularly of the NA system, appear to be useful additional markers for allogeneic bone marrow engraftment.

References

Feb 1, 1979·Tissue Antigens·F H ClaasJ J van Rood
May 1, 1971·The Journal of Clinical Investigation·P LalezariF H Allen
Nov 1, 1966·The Journal of Clinical Investigation·P Lalezari, G E Bernard

❮ Previous
Next ❯

Citations

Jan 1, 1995·Vox Sanguinis·J BuxC Mueller-Eckhardt
Jun 24, 2000·Transfusion·K MatsuoD Stroncek

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

American Journal of Reproductive Immunology : AJRI
P R MadyasthaD H Levine
© 2021 Meta ULC. All rights reserved