PMID: 6409851Jul 1, 1983Paper

Family studies of the HLA system in acute post-streptococcal glomerulonephritis

Human Immunology
Z LayrisseJ Tiwari

Abstract

Eighteen families (67 siblings) of index cases with acute post-streptococcal glomerulonephritis (APSGN) were typed for HLA-A,B,C,DR antigens. Twenty cases of clinical nephritis and 10 cases of asymptomatic disease with detected among the sibships. In eight families with more than one affected individual comprising 18 sib pairs random segregation of paternal and maternal HLA haplotypes was found (0.5 less than p less than 0.06), but some antigens (CW1, DR3) showed deviation from the expected 1:1 ratio in affected and nonaffected siblings in backcross families. We had previously noticed the existence of Mendelian recessive ratios in APSGN but in the absence of clear evidence for a dominant or recessive mode of inheritance for a putative APSGN susceptibility gene(s), pedigree data were analyzed twice for linkage with HLA using the two genetic models. The data obtained, although not sufficient to reject the hypothesis of linkage, provide no support for it. Comparison of the frequency of 61 HLA antigens among 42 unrelated APSGN patients and 109 controls, showed that HLA-DRW4 is more frequent among the former (pc = 0.0500).

References

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Aug 15, 1982·Experientia·B Rodríguez-IturbeZ Layrisse

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Citations

Nov 16, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ashraf BakrAmany Salah
Mar 12, 2008·Current Opinion in Pediatrics·Sun-Young Ahn, Elizabeth Ingulli
Aug 1, 1996·Acta Paediatrica·K MoriY Ito
Dec 1, 1987·British Heart Journal·C N RajapakseA K Al-Aska
Jan 11, 2013·Kidney International·Samih H NasrVivette D D'Agati
Mar 8, 2007·Kidney International·B Rodríguez-Iturbe, S Batsford
Apr 22, 2015·Autoimmunity Reviews·William John MartinIan P Wicks
Feb 19, 2000·Scandinavian Journal of Infectious Diseases·A NordstrandS E Holm
Dec 30, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Devinder ToorAnuradha Chakraborti
Nov 8, 2014·PloS One·Nuha Mahmoud HamdiAmr Ekhlas Eid
Oct 9, 2020·International Reviews of Immunology·Jesús Mosquera, Adriana Pedreañez
Feb 4, 2021·Journal of the American Society of Nephrology : JASN·Bernardo Rodriguez-Iturbe
Dec 8, 2009·Pediatric Clinics of North America·Gurmeet R Singh
Sep 1, 1985·Kidney International·W G Couser
Jan 1, 1984·Kidney International·B Rodríguez-Iturbe

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