PMID: 2504309Aug 1, 1989Paper

Family study and frequency of blood group with strong B transferase accompanied by decreased A and H antigens

Blut
R YabeH Yamaguchi

Abstract

Subgroups of type A blood, named A1, A2, and A1-A2 intermediate (Aint), are specifically characterized by their peculiar A alleles and have their own A1-, A2- or Aint-forms of alpha-N-acetyl-D-galactosaminyltransferase (A-transferase). It is known, however, that certain type A2B persons exhibit A1-transferase. The reason may be an unusual alpha-galactosyltransferase (B-transferase). This strong B-transferase competes with A-transferase for the substrate, H antigen, so as to decrease the A and H antigens on the red cells. We studied this blood group over three generations and found that the strong B-transferase is, in fact, inherited with the B gene and is dominant over normal B-transferase. In AB blood groups in Tokyo, the frequency of people with a strong B-transferase is 5% for A1B and 22% for A2B. This enzyme does not always cause weak H or A antigens.

References

Jul 1, 1975·Transfusion·A Simmons, J Twaitt
Jan 1, 1976·Vox Sanguinis·J KościelakW Dzierzkowa-Borodej
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·H SchachterJ H Crookston
Nov 30, 1925·The Journal of Experimental Medicine·K Landsteiner, C P Miller

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Citations

Jun 18, 2010·Transfusion Medicine·B M Sant'Anna GomesE M Do Nascimento

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