FamLinkX - implementation of a general model for likelihood computations for X-chromosomal marker data

Forensic Science International. Genetics
Daniel KlingAndreas O Tillmar

Abstract

The use of genetic markers located on the X chromosome has seen a significant increase in the last years and their utility has been well studied. This paper describes the software FamLinkX, freely available at http://www.famlink.se, implementing a new algorithm for likelihood computations accounting for linkage, linkage disequilibrium and mutations. It is obvious that such software is sought for among forensic users as more and more X-chromosomal markers become available. We provide some simulated examples demonstrating the utility of the implementation as well as its application in forensic casework. Though algebraic derivations are generally unfeasible, the paper outlines some theoretical considerations and provides a discussion on the validation of the software. The focus of this paper is to compare the software to existing methods in a forensic setting, perform a validation study as well as to provide an idea of the discriminatory power for X-chromosomal markers.

References

Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E S Lander, P Green
Jan 1, 1971·Human Heredity·R C Elston, J Stewart
May 10, 2000·Forensic Science International : Synergy·T EgelandM Stenersen
Oct 28, 2005·American Journal of Human Genetics·Gonçalo R Abecasis, Janis E Wigginton
Dec 17, 2008·International Journal of Legal Medicine·Leonor GusmãoAntónio Amorim
Jun 1, 2007·Forensic Science International. Genetics·Reinhard Szibor
Dec 17, 2008·Forensic Science International. Genetics·David W GjertsonNiels Morling
Dec 17, 2008·Forensic Science International. Genetics·Andreas O TillmarKerstin Montelius
Nov 3, 2010·Forensic Science International. Genetics·Vânia PereiraMaria João Prata
Feb 5, 2011·Forensic Science International. Genetics·Jeanett EdelmannSandra Hering
May 20, 2011·Forensic Science International. Genetics·Nádia PintoAntónio Amorim
Jul 1, 2011·International Journal of Legal Medicine·Rui PereiraLeonor Gusmão
Aug 5, 2011·Forensic Science International. Genetics·Andreas O Tillmar
Mar 31, 2012·Forensic Science International. Genetics·Michael NothnagelSandra Hering
Mar 26, 2014·Forensic Science International. Genetics·Daniel KlingAndreas O Tillmar
Aug 13, 2014·Forensic Science International. Genetics·Daniel KlingThore Egeland

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Citations

Nov 29, 2015·International Journal of Legal Medicine·Guro DørumThore Egeland
Sep 26, 2020·Frontiers in Genetics·Vania PereiraLeonor Gusmão
May 27, 2017·International Journal of Legal Medicine·Daniel Kling
Nov 24, 2016·International Journal of Legal Medicine·Tomonori TamuraTakashi Nakamura
Oct 24, 2020·Frontiers in Genetics·Iva GomesAntónio Amorim
Feb 18, 2020·Forensic Science International. Genetics·Nádia PintoLeonor Gusmão
May 26, 2017·Forensic Science International. Genetics·Andreas O TillmarLeonor Gusmão
Apr 23, 2021·Journal of Forensic Sciences·Ran LiJianye Ge
Jun 26, 2021·American Journal of Physical Anthropology·Rodrigo Flores-EspinozaGerman Burgos
Jul 19, 2021·Forensic Science International. Genetics·Hilde Kjelgaard BrustadThore Egeland
Aug 23, 2021·International Journal of Legal Medicine·Michel BottinelliMartin Zieger

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