Famotidine polymorphic transformation in the grinding process significantly depends on environmental humidity or water content

International Journal of Pharmaceutics
Wen-Ting Cheng, Shan-Yang Lin

Abstract

The effect of environmental humidity and additional water added on the polymorphic change of famotidine in the process of grinding was investigated. The famotidine form B powder with or without additional amount of water added was respectively ground for 30 min in an oscillatory ball mill under 25+/-2 degrees C and three relative humidities (RH) (50+/-5%, 75+/-5% or 95+/-5% RH). Each ground sample was periodically isolated for analytical determinations by using differential scanning calorimetry (DSC), thermogravimetric (TG) analysis and Fourier transform infrared (FT-IR) microspectroscopy. The results indicate that the higher environmental humidity might induce and promote the polymorphic transformation of famotidine from form B to form A in the process of grinding. Moreover, the more the amount of water externally added the easier the polymorphic transformation of famotidine from form B to form A obtained. In addition, the more grinding time spent the more formation of form A obtained. This study disavowed the results of other studies in which no polymorphic change of famotidine even by grinding. The apparent evidence shows that the solid-state polymorphic transformation of famotidine from form B to form A in the grinding proc...Continue Reading

Citations

Nov 7, 2009·Journal of Pharmaceutical Sciences·Harry G Brittain
Dec 12, 2012·The Journal of Pharmacy and Pharmacology·Jianjun ZhangShuai Qian
Jun 19, 2015·Molecular Pharmaceutics·Inese SarcevičaLászló Fábián
Dec 5, 2017·Journal of Surfactants and Detergents·Ilona Kiszkiel-TaudulMonika Kasabuła
Jul 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magdalena PaczkowskaJudyta Cielecka-Piontek
Dec 22, 2020·Frontiers in Bioengineering and Biotechnology·Munair BadshahTaous Khan
May 31, 2021·Journal of Pharmaceutical and Biomedical Analysis·Marina AntonioRubén M Maggio

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