Abstract
For long times astrocytes had been regarded as supporting cells, passively filling the spaces between neuronal cell bodies and their extensions. Now it is known that astrocytes are actively involved in a variety of important biological functions such as regulating cerebral blood flow, supporting neuronal metabolism, controlling the extracellular potassium concentration, and clearing neurotransmitters from the extracellular space. In line with this multitude of tasks astrocytes display conspicuous functional and regional heterogeneity. Using three complementary labeling methods nine classes of astrocytes have been differentiated, which were termed protoplasmic, fibrous, velate, radial, and perivascular astrocytes in addition to Bergmann, marginal, and ependymal glial cells. To complete this list retinal Müller cells and a largely forgotten astrocytic cell type, the "feathered cell" of Fañanas need to be added. So far, Fañanas cells could be only recognized with the tedious gold-sublimate procedure. Consequently, data indicating a potential biological function are completely missing. In a parallel investigation we used a battery of antibodies against potassium channels and related proteins to identify potential marker proteins fo...Continue Reading
References
Nov 22, 1991·The Journal of Comparative Neurology·H HolländerJ Stone
Jul 1, 1982·Neuroscience·P Somogyi, H Takagi
Apr 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M LafargaJ Berciano
Dec 26, 2001·Molecular and Cellular Neurosciences·A ThomzigR W Veh
Mar 16, 2007·Neuron Glia Biology·Jason G Emsley, Jeffrey D Macklis
Dec 17, 2009·Brain Research Reviews·Vitali Matyash, Helmut Kettenmann
Jul 27, 2010·Current Opinion in Neurobiology·Ye Zhang, Ben A Barres
Apr 12, 2012·The Journal of Comparative Neurology·René Bernard, Rüdiger W Veh
Nov 14, 2012·Developmental Neuroscience·Lesley S Chaboub, Benjamin Deneen
Aug 29, 2013·Progress in Neurobiology·Annalisa Buffo, Ferdinando Rossi
Nov 22, 2014·Cold Spring Harbor Perspectives in Biology·Omer Ali BayraktarDavid H Rowitch
Jul 25, 2017·Scientific Reports·Julia AhlfeldUlrich Schüller
Aug 20, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lydie MorelYongjie Yang
Citations
Jun 21, 2019·The Cerebellum·Ana Paula Bergamo AraujoFlávia Carvalho Alcantara Gomes
Oct 23, 2019·Frontiers in Cellular Neuroscience·Jason S Gill, Roy V Sillitoe
Nov 16, 2020·Molecular Psychiatry·Lydia LebenheimRüdiger W Veh
Jun 2, 2021·Journal of Neuroscience Research·Christina Geraldine KantzerAndreas Bosio