FANCF methylation contributes to chemoselectivity in ovarian cancer

Cancer Cell
Olufunmilayo I Olopade, Minjie Wei

Abstract

A new model of ovarian cancer tumor progression implicates aberrant FANCF promoter methylation that is associated with gene silencing and disruption of the Fanconi-anemia-BRCA pathway. Disruption of the pathway occurs de novo in ovarian cancers and may contribute to selective sensitivity to platinum salts.

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