Fanconi anaemia proteins: major roles in cell protection against oxidative damage

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Giovanni Pagano, Hagop Youssoufian

Abstract

Fanconi anaemia (FA) is a cancer-prone genetic disorder that is characterised by cytogenetic instability and redox abnormalities. Although rare subtypes of FA (B, D1 and D2) have been implicated in DNA repair through links with BRCA1 and BRCA2, such a role has yet to be demonstrated for gene products of the common subtypes. Instead, these products have been strongly implicated in xenobiotic metabolism and redox homeostasis through interactions of FANCC with cytochrome P-450 reductase and with glutathione S-transferase, and of FANCG with cytochrome P-450 2E1, as well as redox-dependent signalling through an interaction between FANCA and Akt kinase. We hypothesise that FA proteins act directly (via FANCC and FANCG) and indirectly (via FANCA, BRCA2 and FANCD2) with the machinery of cellular defence to modulate oxidative stress. The latter interactions may co-ordinate the link between the response to DNA damage and oxidative stress parameters (3, 6-12).

References

Sep 1, 1991·Toxicology and Applied Pharmacology·J W BaumanC D Klaassen
Dec 8, 1989·Biochimica Et Biophysica Acta·M d'IschiaG Prota
Dec 1, 1986·Human Genetics·H Joenje, A B Oostra
Jan 1, 1982·Human Genetics·E H PollA W Eriksson
Oct 1, 1996·American Journal of Hematology·B P Alter
Jun 1, 1997·Human Genetics·W RuppitschM Hirsch-Kauffmann
Oct 17, 1998·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·V VulpisA Pirrelli
Dec 10, 1998·Cell Death and Differentiation·F EspositoF Cimino
Apr 27, 2000·FEBS Letters·N TakaoK Yamamoto
Apr 21, 2001·Oncogene·W R Taylor, G R Stark
Jul 18, 2001·The Journal of Biological Chemistry·P G PenkethA C Sartorelli
Oct 11, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·B S De Martinis, M D Bianchi
Nov 15, 2001·The Journal of Biological Chemistry·Jonathan P GodboutGregory G Freund
Feb 22, 2002·Biochemical and Biophysical Research Communications·Tetsuya OtsukiKeiya Ozawa

❮ Previous
Next ❯

Citations

Oct 19, 2007·Zeitschrift für Gerontologie und Geriatrie·K NevelingH Hoehn
Jun 29, 2013·The International Journal of Biochemistry & Cell Biology·Sunshin KimChang-Hun Lee
Jun 7, 2005·Biochimie·Gaëtane MacéFilippo Rosselli
Jun 17, 2004·Genes & Development·Jordi SurrallésHans Joenje
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Odile Cohen-HaguenauerMichel Marty
May 17, 2008·Journal of Biomedicine & Biotechnology·Henning WillersSimon N Powell
Jan 26, 2005·Environmental and Molecular Mutagenesis·Larry H ThompsonNigel J Jones
Oct 25, 2006·The Journal of Cell Biology·Sudit S MukhopadhyaySharon E Plon
Dec 26, 2009·Cancer Letters·Lisa A KachnicHenning Willers
Dec 7, 2007·Free Radical Biology & Medicine·Ana LloretGiovanni Pagano
Jul 9, 2004·British Journal of Haematology·Marc Tischkowitz, Inderjeet Dokal
Jul 8, 2005·European Journal of Haematology·Giovanni PaganoAdriana Zatterale
Feb 2, 2012·Pediatric Blood & Cancer·Susan R RoseStella M Davies
Jul 28, 2011·Pediatric Blood & Cancer·L'Aurelle A JohnsonPamala A Jacobson
Feb 2, 2010·Environmental and Molecular Mutagenesis·Gaëtane Macé-AiméMurat K Saparbaev
Sep 11, 2013·Pediatric Blood & Cancer·Susan R RoseFranklin O Smith
Aug 15, 2006·Pathologie-biologie·G MacéF Rosselli
Jun 21, 2006·DNA Repair·Allan M Gurtan, Alan D D'Andrea
Mar 23, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Nataliya V SavinaRoza I Goncharova
Aug 21, 2004·Blood·Sonia FrancoMaría A Blasco
Oct 18, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nan MeiMichael Weinfeld
Feb 7, 2004·The Journal of Biological Chemistry·M Reza SaadatzadehLaura S Haneline
May 13, 2004·The Journal of Biological Chemistry·Su-Jung ParkSuk-Hee Lee
Jun 15, 2018·Molecular Medicine Reports·Sirikul KulanuwatNattachet Plengvidhya
Nov 3, 2021·Journal of the American Chemical Society·Aaron L Rozelle, Seongmin Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.