PMID: 2101869Jan 1, 1990Paper

Fanconi's anemia: genetic and molecular aspects of the defect

Nouvelle Revue Française D'hématologie
E MoustacchiD Papadopoulo

Abstract

Several features of Fanconi's anemia (FA) are reported: relative inefficiency in the processing of DNA cross-links and monoadducts, hypomutability at the two loci analysed, complementation of the cytogenetic defect by cocultivation with mouse cells and homology of the FA group A with the mouse cellular mutant MCS attempts to clone and characterise a DNA fragment which complements the defect. The relation between observed features and predisposition to leukemia are discussed.

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