PMID: 6978105Apr 1, 1982Paper

Fanconi's anemia. Tumor-like warts, hyperpigmentation associated with deranged keratinocytes, and depressed cell-mediated immunity

Archives of Dermatology
E JohanssonS Pyrhönen

Abstract

A 27-year-old man had had Fanconi's anemia (FA) for 20 years. The patient had pancytopenia, retarded growth, hypogonadism, and chromosomal aberrations. He had freckle-like and darker pigmented macules scattered on his chest, shoulders, upper part of the back, and hips, with interspersed, hypopigmented areas. Biopsy specimens taken from both the hyperpigmented and hypopigmented spots showed a derangement of keratinocytes and nuclear abnormalities, more notable on sun-exposed skin sites. The patient also had numerous tumor-like, recalcitrant, viral warts. Immunologic studies showed normal humoral immunity, but there was evidence of depressed cell-mediated immunity. We speculate that the chromosomal aberrations, the depressed cell-mediated immunity, and the increased frequency of malignant neoplasms known to occur in patients with FA also reflect changes related to an increased susceptibility to viral infections.

Citations

Jan 1, 1994·International Journal of Dermatology·T Lotti
Jun 28, 2012·Anemia·Tagrid Kaddar, Madeleine Carreau
Jul 1, 1995·Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association·G R SomersD J Venter
Sep 27, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·M Saez-de-OcarizR Ruiz-Maldonado
May 1, 1983·British Journal of Obstetrics and Gynaecology·H H MorrisD Y Mason
Jun 1, 1988·International Journal of Dermatology·T T RogozinskiM Jarzabek-Chorzelska
Oct 1, 1985·Clinics in Dermatology·Y ChardonnetJ Thivolet
Oct 1, 1985·Clinics in Dermatology·M A Lutzner

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