Fanconi's syndrome, interstitial fibrosis and renal failure by aristolochic acid in Chinese herbs

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Yin-Tai HongChin-Shiang Chi

Abstract

Aristolochic acid-associated nephropathy (AAN) has been identified as a separate entity of progressive tubulo-interstitial nephropathy. Its characteristic pathological findings, including hypocellular interstitial fibrosis, intimal thickening of interlobular and afferent arterioles with glomeruli sparing or mild sclerosis, have been identified. Many cases of AAN in adults have been reported in Taiwan as well as throughout the world, but it has seldom been described in children. We report on a 10-year-old boy who presented with severe anemia, Fanconi's syndrome, and progressive renal failure. Renal biopsy revealed typical findings of AAN. Aristolochic acids I and II were identified from a Chinese herb mixture ingested by the boy. AAN was diagnosed after other etiologies had been excluded. The case demonstrates the hazards of Chinese herbs with regard to children's health in Taiwan and suggests that more attention should be paid to this issue.

References

Jan 15, 1994·Lancet·M VanhaelenJ L Vanherweghem
Aug 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M DepierreuxJ L Vanherweghem
Apr 30, 1994·BMJ : British Medical Journal·B I Vander StrichtD Quertinier
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E GoffinC van Ypersele de Strihou
Feb 17, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C S YangH C Hsu
Jun 8, 2000·The New England Journal of Medicine·J L NortierJ L Vanherweghem
Feb 7, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·B KrummeD Walb
Dec 24, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jean-Pierre Cosyns
Jun 11, 2004·Nephrology·Xiaomei Li, Haiyan Wang
Jun 24, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Corinne Isnard BagnisJean Louis Vanherweghem

❮ Previous
Next ❯

Citations

Apr 29, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Justine BacchettaPierre Cochat
May 23, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Xiang XueJin Ren
Jul 9, 2010·Nephrology·Vivekanand Jha
Jul 9, 2011·Advances in Pharmacological Sciences·Chiao-Shih TsengKuang-Yang Hsu
Jun 23, 2009·Journal of Epidemiology·Su-Ying TsaiChia-Chu Chang
May 3, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jinn-Yuh GuhLea-Yea Chuang
May 13, 2010·Histopathology·Agnieszka A PozdzikJoëlle L Nortier
Oct 16, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Darcy K WeidemannJeffrey J Fadrowski
Jan 5, 2013·Journal of Ethnopharmacology·Ellie J Y KimGeorge Q Li
Feb 2, 2017·International Journal of Molecular Sciences·Inès JadotNathalie Caron
Apr 5, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Bo YangClaudio Ronco
Apr 14, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vijaya SathyanarayanaStefan Meyer
May 26, 2021·Critical Reviews in Toxicology·Suparmi SuparmiIvonne M C M Rietjens
Jun 4, 2021·Frontiers in Pharmacology·Yan-Zhuan XiaoJames Cheng-Chung Wei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.