Abstract
Aristolochic acid-associated nephropathy (AAN) has been identified as a separate entity of progressive tubulo-interstitial nephropathy. Its characteristic pathological findings, including hypocellular interstitial fibrosis, intimal thickening of interlobular and afferent arterioles with glomeruli sparing or mild sclerosis, have been identified. Many cases of AAN in adults have been reported in Taiwan as well as throughout the world, but it has seldom been described in children. We report on a 10-year-old boy who presented with severe anemia, Fanconi's syndrome, and progressive renal failure. Renal biopsy revealed typical findings of AAN. Aristolochic acids I and II were identified from a Chinese herb mixture ingested by the boy. AAN was diagnosed after other etiologies had been excluded. The case demonstrates the hazards of Chinese herbs with regard to children's health in Taiwan and suggests that more attention should be paid to this issue.
References
Jan 15, 1994·Lancet·M VanhaelenJ L Vanherweghem
Aug 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M DepierreuxJ L Vanherweghem
Feb 13, 1993·Lancet·J L VanherweghemR Vanhaelen-Fastre
Apr 30, 1994·BMJ : British Medical Journal·B I Vander StrichtD Quertinier
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E GoffinC van Ypersele de Strihou
Jan 1, 1997·Kidney International·J L NortierJ L Vanherweghem
Feb 17, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C S YangH C Hsu
Jun 8, 2000·The New England Journal of Medicine·J L NortierJ L Vanherweghem
Feb 7, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·B KrummeD Walb
Sep 29, 2001·Kidney International·C LebeauR Beauwens
Dec 24, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jean-Pierre Cosyns
Jun 11, 2004·Nephrology·Xiaomei Li, Haiyan Wang
Jun 11, 2004·Nephrology·Sangho LeeMyungjae Kim
Jun 24, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Corinne Isnard BagnisJean Louis Vanherweghem
Citations
Apr 29, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Justine BacchettaPierre Cochat
May 23, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Xiang XueJin Ren
Jul 9, 2010·Nephrology·Vivekanand Jha
Jul 9, 2011·Advances in Pharmacological Sciences·Chiao-Shih TsengKuang-Yang Hsu
Jan 17, 2013·BMC Nephrology·Hong Ki MinHyeon Seok Hwang
Jun 23, 2009·Journal of Epidemiology·Su-Ying TsaiChia-Chu Chang
Nov 29, 2014·BioMed Research International·Hsiao-Yu YangJung-Der Wang
May 3, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jinn-Yuh GuhLea-Yea Chuang
May 13, 2010·Histopathology·Agnieszka A PozdzikJoëlle L Nortier
Oct 16, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Darcy K WeidemannJeffrey J Fadrowski
Apr 7, 2011·Journal of Ethnopharmacology·H Y YangY J Lou
Jan 5, 2013·Journal of Ethnopharmacology·Ellie J Y KimGeorge Q Li
Jun 21, 2012·Biochemical and Biophysical Research Communications·Yi-Chieh LiJen-Ai Lee
Feb 2, 2017·International Journal of Molecular Sciences·Inès JadotNathalie Caron
Apr 5, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Bo YangClaudio Ronco
Apr 14, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vijaya SathyanarayanaStefan Meyer
Jul 2, 2020·Neuropsychiatric Disease and Treatment·Yueh-Er ChiouNian-Sheng Tzeng
Nov 6, 2020·3 Biotech·Remya UnnikrishnanR Jayaraj
May 26, 2021·Critical Reviews in Toxicology·Suparmi SuparmiIvonne M C M Rietjens
Jun 4, 2021·Frontiers in Pharmacology·Yan-Zhuan XiaoJames Cheng-Chung Wei