Fantastic nuclear envelope herniations and where to find them

Biochemical Society Transactions
David J Thaller, C Patrick Lusk

Abstract

Morphological abnormalities of the bounding membranes of the nucleus have long been associated with human diseases from cancer to premature aging to neurodegeneration. Studies over the past few decades support that there are both cell intrinsic and extrinsic factors (e.g. mechanical force) that can lead to nuclear envelope 'herniations', a broad catch-all term that reveals little about the underlying molecular mechanisms that contribute to these morphological defects. While there are many genetic perturbations that could ultimately change nuclear shape, here, we focus on a subset of nuclear envelope herniations that likely arise as a consequence of disrupting physiological nuclear membrane remodeling pathways required to maintain nuclear envelope homeostasis. For example, stalling of the interphase nuclear pore complex (NPC) biogenesis pathway and/or triggering of NPC quality control mechanisms can lead to herniations in budding yeast, which are remarkably similar to those observed in human disease models of early-onset dystonia. By also examining the provenance of nuclear envelope herniations associated with emerging nuclear autophagy and nuclear egress pathways, we will provide a framework to help understand the molecular pat...Continue Reading

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Citations

Jan 9, 2020·The FEBS Journal·Irina L RempelLiesbeth M Veenhoff
Jun 13, 2020·Molecular Biology of the Cell·Shirin Bahmanyar, Christian Schlieker
Jun 26, 2020·The Journal of Cell Biology·Angelina Sarah Gross, Martin Graef
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Sep 22, 2018·Histochemistry and Cell Biology·Carmen AdriaensTom Misteli
Feb 8, 2020·Nature Cell Biology·Chia-Wei LeeBoris Pfander
Apr 29, 2020·The Journal of Cell Biology·Anthony J RampelloChristian Schlieker
Jan 20, 2021·The Journal of Cell Biology·David J ThallerC Patrick Lusk
Feb 11, 2021·Trends in Biochemical Sciences·Javier Fernandez-Martinez, Michael P Rout
Oct 15, 2020·The Journal of Cell Biology·Christopher L Lord, Susan R Wente
May 20, 2021·Molecular Biology of the Cell·Sapan BorahC Patrick Lusk
Jul 23, 2021·Proceedings of the National Academy of Sciences of the United States of America·Dimitra PanagakiJohanna L Höög
Oct 15, 2021·Nature·Anthony P SchullerThomas U Schwartz

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