Fantastic voyage: the journey of intestinal microbiota-derived microvesicles through the body.

Biochemical Society Transactions
Régis StentzSimon R Carding

Abstract

As part of their life cycle, Gram-negative bacteria produce and release microvesicles (outer membrane vesicles, OMVs) consisting of spherical protrusions of the outer membrane that encapsulate periplasmic contents. OMVs produced by commensal bacteria in the gastrointestinal (GI) tract of animals are dispersed within the gut lumen with their cargo and enzymes being distributed across and throughout the GI tract. Their ultimate destination and fate is unclear although they can interact with and cross the intestinal epithelium using different entry pathways and access underlying immune cells in the lamina propria. OMVs have also been found in the bloodstream from which they can access various tissues and possibly the brain. The nanosize and non-replicative status of OMVs together with their resistance to enzyme degradation and low pH, alongside their ability to interact with the host, make them ideal candidates for delivering biologics to mucosal sites, such as the GI and the respiratory tract. In this mini-review, we discuss the fate of OMVs produced in the GI tract of animals with a focus on vesicles released by Bacteroides species and the use of OMVs as vaccine delivery vehicles and other potential applications.

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Jul 20, 2019·Biochemical Society Transactions·Carolina Coelho, Arturo Casadevall
Oct 17, 2020·Oncogene·Antonios Chronopoulos, Raghu Kalluri
Dec 2, 2020·International Journal of Molecular Sciences·Sandor Haas-Neill, Paul Forsythe
Jan 13, 2021·Molecular Microbiology·Jolene M GarberChristine M Szymanski
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Apr 18, 2021·Autoimmunity Reviews·Fataneh Tavasolian, Robert D Inman
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Jun 3, 2021·International Journal of Molecular Sciences·María Fernanda GonzálezAndrew F G Quest
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Oct 13, 2021·The EMBO Journal·Hannah M McMillan, Meta J Kuehn
Nov 6, 2021·Journal of Extracellular Vesicles·Natalia Díaz-GarridoLaura Baldomà

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Methods Mentioned

BETA
PCRs

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