Farm-level impact of therapeutic antimicrobial use on antimicrobial-resistant populations of Escherichia coli isolates from pigs

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Kazuki HaradaToshio Takahashi

Abstract

We investigated the farm-level impact of the use of several different antimicrobial agents on the population of antimicrobial-resistant commensal bacteria of animal origin to appropriately assess the release risk of resistance. This study was carried out based on the results of a survey on the history of antimicrobial drug use in 297 pig farms and antimicrobial susceptibility testing for the 545 Escherichia coli isolates (one or two isolates/pig/farm). A comparative analysis with the nonexposed herd revealed that ampicillin (ABPC) resistance in E. coli increased in the herds that were exposed to penicillin (relative risk [RR], 1.75) and penicillin-streptomycin (RR, 2.28); dihydrostreptomycin (DSM) resistance, in the penicillin-streptomycin-exposed herd (RR, 1.75); and trimethoprim (TMP) resistance in the methoprim-sulfonamide-exposed herd (RR, 2.10). On the other hand, ABPC and DSM resistances increased in the tetracycline-exposed herd (RR, 1.66 and 1.58, respectively); TMP resistance, in the penicillin-exposed herd (RR, 1.77); and oxytetracycline and kanamycin resistances, in the penicillin-streptomycin-exposed herd (RR, 1.28 and 2.22, respectively). These results demonstrated that the development of cross-resistance and cores...Continue Reading

References

May 29, 1999·Applied and Environmental Microbiology·A G MathewS E Chattin
May 5, 2000·International Journal of Antimicrobial Agents·J L MartelE Chaslus-Dancla
Jun 9, 2001·International Journal of Antimicrobial Agents·S SchwarzT R Walsh
Jul 4, 2001·Veterinary Research·S Schwarz, E Chaslus-Dancla
Apr 2, 2003·Journal of Veterinary Pharmacology and Therapeutics·B CatryA De Kruif
Sep 21, 2005·Critical Reviews in Microbiology·Trudy M Wassenaar
Sep 28, 2006·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Julie A FunkPäivi J Rajala-Schultz
Oct 12, 2007·Future Microbiology·Jeffrey M GilbertPatrick F McDermott

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Citations

Aug 22, 2015·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Kohei MakitaYutaka Tamura
Oct 16, 2015·Critical Reviews in Food Science and Nutrition·Maurizio FerriValerio Giaccone
May 17, 2017·Animal Health Research Reviews·Yrjo T GrohnVictoriya Volkova

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