Farnesol inhibits in vitro growth of the Cryptococcus neoformans species complex with no significant changes in virulence-related exoenzymes

Veterinary Microbiology
Rossana de Aguiar CordeiroMarcos Fábio Gadelha Rocha

Abstract

Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans. In recent years, several studies have shown that this molecule presents inhibitory effects against non-albicans Candida species, Paracoccidioides brasiliensis and bacteria. The present study aimed at determining the effect of farnesol on the growth of strains of the Cryptococcus neoformans species complex, through microdilution assays. In addition, the effect of farnesol on the synthesis of phospholipase and protease - important virulence-associated enzymes - by C. neoformans and Cryptococcus gattii was also investigated. A total of 36 strains were studied, out of which 20 were from veterinary sources, 8 were from human cases and 8 were from a reference collection. The minimum inhibitory concentrations (MICs) were determined in accordance with the M27-A3 protocol as described by the CLSI and farnesol was tested at a concentration range of 0.29-150 μM. Phospholipase and protease activities were evaluated through growth on egg yolk agar and spectrophotometry, respectively, after pre-incubating the strains at different farnesol concentrations (MIC/4, MIC/2 and MIC). It was observed that farnesol presents an inhibitory activity agains...Continue Reading

References

Jun 27, 2001·Applied and Environmental Microbiology·J M HornbyK W Nickerson
Feb 27, 2003·Emerging Infectious Diseases·Wieland MeyerUNKNOWN IberoAmerican Cryptococcal Study Group
May 25, 2004·Antimicrobial Agents and Chemotherapy·Jacob M Hornby, Kenneth W Nickerson
Oct 9, 2004·Journal of Clinical Microbiology·Luciana TrillesJosep Guarro
Oct 22, 2005·The Journal of Antimicrobial Chemotherapy·Dhammika H M L P NavarathnaKenneth W Nickerson
May 16, 2006·FEMS Yeast Research·Kyung J Kwon-Chung, Ashok Varma
May 18, 2006·Annual Review of Microbiology·Xiaorong Lin, Joseph Heitman
Oct 18, 2006·FEMS Yeast Research·Mary Ann Jabra-RizkTimothy Meiller
Oct 2, 2007·The Journal of Infection·Elio CenciAnna Vecchiarelli
Jan 19, 2008·FEMS Microbiology Letters·Camile P SemighiniSteven D Harris
Aug 1, 2008·Microbiology and Immunology·Tatsuya HisajimaShigeru Abe
Apr 15, 2009·Antimicrobial Agents and Chemotherapy·Mark E ShirtliffMary Ann Jabra-Rizk
May 1, 2009·Annals of Clinical Microbiology and Antimicrobials·Lorena S DerengowskiIldinete Silva-Pereira
Nov 26, 2009·Antimicrobial Agents and Chemotherapy·Melanie L LangfordAudrey L Atkin
Dec 17, 2009·Journal of Clinical Microbiology·Naureen IqbalUNKNOWN Cryptococcus gattii Public Health Working Group
Nov 3, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jing JinLu Yu
Jan 19, 2011·FEMS Microbiology Ecology·Raimunda S N BrilhanteMarcos F G Rocha
Jan 20, 2011·Veterinary Clinical Pathology·Sally J LesterColleen G Duncan
Feb 18, 2011·Nature Reviews. Microbiology·James W KronstadJoyce Wang
Apr 2, 2011·Molecular Microbiology·Methee ChayakulkeereeJulianne Teresa Djordjevic

❮ Previous
Next ❯

Citations

Mar 6, 2013·Antimicrobial Agents and Chemotherapy·Raimunda Sâmia Nogueira BrilhanteMarcos Fábio Gadelha Rocha
Nov 6, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Erica Biolcati P da SilvaJoão Henrique G Lago
Aug 6, 2015·Cellular Microbiology·Emily F Dixon, Rebecca A Hall
Feb 7, 2015·Journal of Medical Microbiology·Raimunda Sâmia Nogueira BrilhanteMarcos Fábio Gadelha Rocha
Jan 21, 2020·Expert Opinion on Therapeutic Patents·Gyllyandeson De Araújo DelmondesMarta Regina Kerntopf
Nov 3, 2020·International Journal of Biological Macromolecules·Lana Glerieide Silva GarciaRaimunda Sâmia Nogueira Brilhante
Apr 21, 2021·Medical Mycology·Adelaide Fernandes CostaAndre Correa Amaral
May 29, 2018·Carbohydrate Polymers·Lana Glerieide Silva GarciaRaimunda Sâmia Nogueira Brilhante

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.